Analytical Data
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Gene name
PDLIM4
- Application
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Alternative Names
Enigma homolog; LIM domain protein; LIM domain protein RIL; LIM protein RIL; PDLI4_HUMAN; PDLIM 4; PDLIM4; PDZ and LIM domain 4; PDZ and LIM domain protein 4; Reversion induced LIM protein; Reversion-induced LIM protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P50479
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Expression Region
1-330 aa
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AA Sequence
MPHSVTLRGP SPWGFRLVGG RDFSAPLTIS RVHAGSKAAL AALCPGDLIQ AINGESTELM THLEAQNRIK GCHDHLTLSV SRPEGRSWPS APDDSKAQAH RIHIDPEIQD GSPTTSRRPS GTGTGPEDGR PSLGSPYGQP PRFPVPHNGS SEATLPAQMS TLHVSPPPSA DPARGLPRSR DCRVDLGSEV YRMLREPAEP VAAEPKQSGS FRYLQGMLEA GEGGDWPGPG GPRNLKPTAS KLGAPLSGLQ GLPECTRCGH GIVGTIVKAR DKLYHPECFM CSDCGLNLKQ RGYFFLDERL YCESHAKARV KPPEGYDVVA VYPNAKVELV
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Molecular Weight
35.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PDLIM4 (PDZ and LIM domain protein 4) is a member of the PDZ-LIM protein family, which has been implicated in various cellular processes, including cytoskeletal organization, signal transduction, and gene expression regulation. Recent studies have highlighted the potential role of PDLIM4 in cancer, particularly in regulating cell proliferation, apoptosis, and differentiation. Its expression is often altered in several cancer types, suggesting that PDLIM4 may function as a tumor suppressor or an oncogene depending on the context. Given its diverse interactions with other proteins, including those involved in signaling pathways and cell adhesion, the functional characterization of PDLIM4 through recombinant protein studies is essential. This research could elucidate the molecular mechanisms by which PDLIM4 influences cellular functions and contributes to tumorigenesis. By examining its structure, binding partners, and downstream effects, scientists aim to uncover the therapeutic potential of targeting PDLIM4 in cancer treatment. Understanding the biology of PDLIM4 could offer new insights into its role in health and disease, opening avenues for innovative therapeutic strategies.
