Analytical Data
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Gene name
PDE7B
- Application
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Alternative Names
PDE7B; cAMP-specific 3'.5'-cyclic phosphodiesterase 7B; EC 3.1.4.53
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NP56
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Expression Region
1-450 aa
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AA Sequence
MSCLMVERCG EILFENPDQN AKCVCMLGDI RLRGQTGVRA ERRGSYPFID FRLLNSTTYS GEIGTKKKVK RLLSFQRYFH ASRLLRGIIP QAPLHLLDED YLGQARHMLS KVGMWDFDIF LFDRLTNGNS LVTLLCHLFN THGLIHHFKL DMVTLHRFLV MVQEDYHSQN PYHNAVHAAD VTQAMHCYLK EPKLASFLTP LDIMLGLLAA AAHDVDHPGV NQPFLIKTNH HLANLYQNMS VLENHHWRST IGMLRESRLL AHLPKEMTQD IEQQLGSLIL ATDINRQNEF LTRLKAHLHN KDLRLEDAQD RHFMLQIALK CADICNPCRI WEMSKQWSER VCEEFYRQGE LEQKFELEIS PLCNQQKDSI PSIQIGFMSY IVEPLFREWA HFTGNSTLSE NMLGHLAHNK AQWKSLLPRQ HRSRGSSGSG PDHDHAGQGT ESEEQEGDSP
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Molecular Weight
51.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PDE7B (phosphodiesterase 7B) is a member of the phosphodiesterase family, which plays a crucial role in regulating intracellular levels of cyclic adenosine monophosphate (cAMP), a key signaling molecule involved in various physiological processes. Aberrant cAMP signaling is implicated in neurological disorders, including schizophrenia and depression, making PDE7B a potential therapeutic target. Recent studies have highlighted the importance of PDE7B in modulating synaptic plasticity and cognitive functions, linking its activity to memory and learning. Furthermore, genetic variations in the PDE7B gene have been associated with an increased risk of psychiatric disorders, underscoring the relevance of this enzyme in mental health. The development of recombinant PDE7B proteins has enabled researchers to investigate its structural and functional properties, paving the way for drug discovery efforts aimed at modulating its activity. By studying PDE7B's interactions with various ligands and its enzymatic kinetics, scientists hope to better understand its role in neuronal signaling and to identify potential inhibitors that could lead to novel treatments for neuropsychiatric conditions.
