Analytical Data
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基因名
PDE7B
- Application
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别名
PDE7B; cAMP-specific 3'.5'-cyclic phosphodiesterase 7B; EC 3.1.4.53
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NP56
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表达区间
1-450 aa
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氨基酸序列
MSCLMVERCG EILFENPDQN AKCVCMLGDI RLRGQTGVRA ERRGSYPFID FRLLNSTTYS GEIGTKKKVK RLLSFQRYFH ASRLLRGIIP QAPLHLLDED YLGQARHMLS KVGMWDFDIF LFDRLTNGNS LVTLLCHLFN THGLIHHFKL DMVTLHRFLV MVQEDYHSQN PYHNAVHAAD VTQAMHCYLK EPKLASFLTP LDIMLGLLAA AAHDVDHPGV NQPFLIKTNH HLANLYQNMS VLENHHWRST IGMLRESRLL AHLPKEMTQD IEQQLGSLIL ATDINRQNEF LTRLKAHLHN KDLRLEDAQD RHFMLQIALK CADICNPCRI WEMSKQWSER VCEEFYRQGE LEQKFELEIS PLCNQQKDSI PSIQIGFMSY IVEPLFREWA HFTGNSTLSE NMLGHLAHNK AQWKSLLPRQ HRSRGSSGSG PDHDHAGQGT ESEEQEGDSP
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分子量
51.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PDE7B (phosphodiesterase 7B) is a member of the phosphodiesterase family, which plays a crucial role in regulating intracellular levels of cyclic adenosine monophosphate (cAMP), a key signaling molecule involved in various physiological processes. Aberrant cAMP signaling is implicated in neurological disorders, including schizophrenia and depression, making PDE7B a potential therapeutic target. Recent studies have highlighted the importance of PDE7B in modulating synaptic plasticity and cognitive functions, linking its activity to memory and learning. Furthermore, genetic variations in the PDE7B gene have been associated with an increased risk of psychiatric disorders, underscoring the relevance of this enzyme in mental health. The development of recombinant PDE7B proteins has enabled researchers to investigate its structural and functional properties, paving the way for drug discovery efforts aimed at modulating its activity. By studying PDE7B's interactions with various ligands and its enzymatic kinetics, scientists hope to better understand its role in neuronal signaling and to identify potential inhibitors that could lead to novel treatments for neuropsychiatric conditions.
