Analytical Data
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Gene name
PCDHGC5
- Application
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Alternative Names
MGC138286; MGC138288; PCDGM_HUMAN; PCDH-gamma-C5; PCDHGC5; Protocadherin gamma C5; protocadherin gamma subfamily C. 5; protocadherin gamma subfamily C. member 5; Protocadherin gamma-C5
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y5F6
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Expression Region
1-878 aa
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AA Sequence
MGPKTLPQLAGKWQVLCMLSLCCWGWVSGQLRYSVVEESEPGTLVGNVAQDLGLKMTDLLSRRLQLGSEENGRYFSLSLMSGALAVNQKIDRESLCGASTSCLLPVQVVTEHPLELIRVEVEILDLNDNSPSFATPEREMRISESAASGARFPLDSAQDPDVGTNTVSFYTLSPNSHFSLNVKTLKDGKPFPELVLEQQLDREAQARHQLVLTAVDGGTPARSGTTLISVIVLDINDNAPTFQSSVLRVGIPENAPIGTLLLRLNATDPDEGTNGQLDYSFGDHTSEAVRNLFGLDPSSGAIHVLGPIDFEESRFYEIHARARDQGQPAMEGHCVIQVDVGDVNDNAPEVLLASLANPVLESTPVGTVVGLFNVRDRDSGRNGEVSLDISPDLPFQIKPSENHYSLLTSQPLDREATSHYIIELLASDAGSPSLHKHLTIRLNISDVNDNAPRFNQQLYTAYILENRPPGSLLCTVAASDPDTGDNARLTYSIVGNQVQGAPASSFVYVNPEDGRIFAQRTFDYELLQMLQIVVGVRDSGSPPLHANTSLHVFVLDENDNAPAVLHPRPDWEHSAPQRLPRSAPPGSLVTKVTAVDADAGHNAWLSYSLLPQSTAPGLFLVSTHTGEVRTARALLEDDSDTQQVVVLVRDNGDPSLSSTATVLLVLEDEDPEEMPKSSDFLIHPPERSDLTLYLIVALATVSLLSLVTFTFLSAKCLQGNADGDGGGGQCCRRQDSPSPDFYKQSSPNLQVSSDGTLKYMEVTLRPTDSQSHCYRTCFSPASDGSDFTFLRPLSVQQPTALALEPDAIRSRSNTLRERSQVRGSAPPRATPGGGTGEAARPHKGLNLHPLLSGRLGRWLRSTRFSGSLDRLRETRVAD
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Molecular Weight
121.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PCDHGC5, or protocadherin gamma subfamily C5, is a member of the protocadherin family, which plays a crucial role in cell adhesion and signaling in the nervous system. These proteins are known for their involvement in neuronal development, synaptic formation, and the maintenance of neuronal networks. The study of PCDHGC5 has gained attention due to its potential implications in various neurological disorders, including autism spectrum disorders and schizophrenia. Researchers have focused on the structural and functional analysis of the PCDHGC5 protein to understand its role in mediating cell-cell interactions and its influence on cellular signaling pathways. The recombinant protein form of PCDHGC5 allows for detailed examinations of its binding affinities, structural properties, and biological functions in vitro. Techniques such as X-ray crystallography and nuclear magnetic resonance spectroscopy are employed to elucidate its three-dimensional structure and interaction mechanisms. Additionally, functional assays using genetically modified cell lines help to establish the physiological relevance of PCDHGC5 in neural contexts. Understanding this protein’s role could provide insights into its contribution to the molecular underpinnings of neural development and the etiology of related disorders, paving the way for potential therapeutic strategies. As ongoing research continues to uncover the complexities of PCDHGC5, it stands as a promising candidate for future studies aimed at tackling neurological conditions linked to cadherin-mediated processes.
