Analytical Data
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Gene name
Ubc7
- Application
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Alternative Names
Ubc7；UBCE7；Ubiquitin-conjugating enzyme E2 L3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P62253
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Expression Region
1-170aa
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AA Sequence
MTELQSALLL RRQLAELNKN PVEGFSAGLI DDNDLYRWEV LIIGPPDTLY EGGVFKAHLT FPKDYPLRPP KMKFITEIWH PNVDKNGDVC ISILHEPGED KYGYEKPEER WLPIHTVETI MISVISMLAD PNGDSPANVD AAKEWREDRN GEFKRKVARC VRKSQETAFE
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Ubc7, a member of the ubiquitin-conjugating enzyme family, plays a pivotal role in the ubiquitin-proteasome system, which is crucial for regulating protein degradation and maintaining cellular homeostasis. The study of Ubc7 is particularly significant due to its involvement in various cellular processes, including the modulation of protein stability, cell cycle progression, and responses to stress. Ubc7 is known to covalently attach ubiquitin molecules to target proteins, marking them for degradation by the proteasome, thereby controlling protein turnover and preventing the accumulation of damaged or misfolded proteins. Abnormalities in Ubc7 function have been linked to several human diseases, including neurodegenerative disorders, cancers, and infections, underscoring its potential as a therapeutic target. Recent research has focused on elucidating the structure-function relationship of Ubc7, its interacting partners, and the regulatory mechanisms governing its activity. This research aims to develop insights into how Ubc7 contributes to cellular functions and how its dysregulation might lead to disease, offering potential avenues for therapeutic intervention. Understanding Ubc7's role in ubiquitination pathways deepens our grasp of "protein quality control" and opens up possibilities for manipulating these pathways for enhanced protein-based therapies.
