Analytical Data
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Gene name
ARL8
- Application
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Alternative Names
ARL5B; ARL8; ADP-ribosylation factor-like Protein 5B; ADP-ribosylation factor-like Protein 8
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96KC2
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Expression Region
2-179aa
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AA Sequence
GLIFAKLWS LFCNQEHKVI IVGLDNAGKT TILYQFLMNE VVHTSPTIGS NVEEIVVKNT HFLMWDIGGQ ESLRSSWNTY YSNTEFIILV VDSIDRERLA ITKEELYRML AHEDLRKAAV LIFANKQDMK GCMTAAEISK YLTLSSIKDH PWHIQSCCAL TGEGLCQGLE WMTSRIGVR
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Molecular Weight
20.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ARL8 (ADP-ribosylation factor-like protein 8) is a member of the ARF family, which plays a crucial role in membrane trafficking and cytoskeletal dynamics within eukaryotic cells. Initially identified as a protein involved in endosomal transport, ARL8 has garnered attention for its significant role in the movement of lysosomes, particularly in the context of autophagy and cellular stress responses. As a small GTPase, ARL8 is activated by GTP binding, which facilitates its interaction with specific effector proteins that govern various cellular processes. In recent years, researchers have increasingly focused on the functional implications of ARL8 in neurodegenerative diseases, cancer, and immune responses, owing to its involvement in lysosomal positioning and stability. The study of ARL8 recombinant proteins aims to elucidate the mechanisms of its action and regulation, providing potential insights into targeted therapeutic strategies. Understanding the molecular pathways influenced by ARL8 not only enhances our knowledge of cellular homeostasis but also reveals its potential as a biomarker or therapeutic target in pathological conditions where lysosomal function is compromised. Thus, ARL8 represents a promising focus for research in cell biology, with implications for developing interventions in disease processes associated with lysosomal dysfunction.
