Analytical Data
-
Gene name
TYRP1
- Application
-
Alternative Names
TYRP1；CAS2；5.6-dihydroxyindole-2-carboxylic acid oxidase
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P17643
-
Expression Region
1-537aa
-
AA Sequence
MSAPKLLSLGCIFFPLLLFQQARAQFPRQCATVEALRSGMCCPDLSPVSG PGTDRCGSSSGRGRCEAVTADSRPHSPQYPHDGRDDREVWPLRFFNRTCH CNGNFSGHNCGTCRPGWRGAACDQRVLIVRRNLLDLSKEEKNHFVRALDM AKRTTHPLFVIATRRSEEILGPDGNTPQFENISIYNYFVWTHYYSVKKTF LGVGQESFGEVDFSHEGPAFLTWHRYHLLRLEKDMQEMLQEPSFSLPYWN FATGKNVCDICTDDLMGSRSNFDSTLISPNSVFSQWRVVCDSLEDYDTLG TLCNSTEDGPIRRNPAGNVARPMVQRLPEPQDVAQCLEVGLFDTPPFYSN STNSFRNTVEGYSDPTGKYDPAVRSLHNLAHLFLNGTGGQTHLSPNDPIF VLLHTFTDAVFDEWLRRYNADISTFPLENAPIGHNRQYNMVPFWPPVTNT EMFVTAPDNLGYTYEIQWPSREFSVPEIIAIAVVGALLLVALIFGTASYL IRARRSMDEANQPLLTDQYQCYAEEYEKLQNPNQSVV
-
Molecular Weight
87 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TYRP1, or Tyrosinase-related protein 1, is a key enzyme involved in the melanin biosynthesis pathway, playing a crucial role in pigmentation processes in mammals. It is primarily expressed in melanocytes, the cells responsible for producing melanin, and is vital for the formation of eumelanin, the darker form of pigment. Mutations in the TYRP1 gene have been linked to pigmentation disorders, such as albinism and hypersensitivity to UV radiation, highlighting its importance in skin and hair pigmentation. Research into TYRP1 has garnered interest due to its potential implications in understanding dermatological conditions and developing therapies for pigment-related disorders. Additionally, the production of recombinant TYRP1 protein has become a focal point for exploring its biochemical properties, functions, and the structural basis of its enzymatic activity. By generating and studying this protein, researchers aim to unravel the mechanisms underlying melanin synthesis and enhance knowledge that could lead to novel treatments for pigmentation abnormalities, skin cancer, and other associated diseases. Furthermore, recombinant TYRP1 may serve as a valuable tool in cosmetic applications and the study of melanin's role in photoprotection and skin health. Overall, the investigation of TYRP1 and its recombinant protein serves as a critical step towards advancing our understanding of pigmentation biology and its clinical applications.
