Analytical Data
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基因名
PTPN1
- Application
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别名
PTPN1；PTP1B；Tyrosine-Protein phosphatase non-receptor type 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P18031
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表达区间
1-321aa
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氨基酸序列
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHN
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分子量
44.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PTPN1, or Protein Tyrosine Phosphatase, Non-Receptor Type 1, is a critical enzyme involved in the regulation of numerous signaling pathways by dephosphorylating tyrosine residues on target proteins. This regulatory function positions PTPN1 as a key player in various cellular processes, including cell growth, differentiation, and metabolism. Dysregulation of PTPN1 has been implicated in several diseases, particularly cancer and diabetes, making it a prime target for therapeutic intervention. Research into PTPN1 recombinant proteins aims to elucidate its structural and functional properties, providing insights into its role in cellular signaling and disease mechanisms. Understanding the exact mechanisms of PTPN1 action at the molecular level can facilitate the development of novel drugs that inhibit or enhance its activity. Furthermore, PTPN1 recombinant proteins can be utilized as tools in biochemical assays and structural biology studies, advancing our knowledge of protein interactions and post-translational modifications. As such, ongoing studies focus on the production, purification, and characterization of PTPN1 recombinants, as well as their potential applications in both basic research and clinical settings.
