Analytical Data
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Gene name
ARL8A
- Application
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Alternative Names
ARL8A; ARL10B; GIE2ADP-ribosylation factor-like Protein 8A
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96BM9
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Expression Region
1-186aa
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AA Sequence
MIALFNKLLD WFKALFWKEE MELTLVGLQY SGKTTFVNVI ASGQFNEDMI PTVGFNMRKI TKGNVTIKLW DIGGQPRFRS MWERYCRGVS AIVYMVDAAD QEKIEASKNE LHNLLDKPQL QGIPVLVLGN KRDLPGALDE KELIEKMNLS AIQDREICCY SISCKEKDNI DITLQWLIQH SKSRRS
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Molecular Weight
46.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ARL8A, a member of the Arf-like protein family, is a small GTPase that plays a crucial role in cellular processes such as vesicle transport and cellular signaling. Its significance has emerged in the context of neurodegenerative diseases, where it has been implicated in the regulation of autophagy and lysosomal function. Studies have revealed that ARL8A interacts with the autophagosome and lysosome, facilitating the fusion of these organelles and thereby enhancing the degradation of cellular debris. This function is vital for maintaining cellular homeostasis, particularly in neurons that are highly susceptible to the accumulation of damaged proteins and organelles. Furthermore, ARL8A is believed to be involved in immune responses, as it participates in the trafficking of lysosomes within immune cells. Given its role in critical cellular mechanisms, researchers are increasingly focused on characterizing recombinant ARL8A proteins to elucidate their functions and interactions at the molecular level. Understanding these dynamics could shed light on the pathophysiological mechanisms underlying various diseases and may pave the way for the development of therapeutic strategies aimed at modulating ARL8A activity to restore normal cellular function. Overall, the study of recombinant ARL8A proteins holds promise for advancing biomedical research and interventions related to neurodegeneration and immune system disorders.
