Analytical Data
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基因名
NGFR
- Application
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别名
NGFR；TNFRSF16；Tumor necrosis factor receptor superfamily member 16
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P08138
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表达区间
29-427aa
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氨基酸序列
KEACPTGLYTHSGECCKACNLGEGVAQPCGANQTVCEPCLDSVTFSDVVSATEPCKPCTECVGLQSMSAPCVEADDAVCRCAYGYYQDETTGRCEACRVCEAGSGLVFSCQDKQNTVCEECPDGTYSDEANHVDPCLPCTVCEDTERQLRECTRWADAECEEIPGRWITRSTPPEGSDSTAPSTQEPEAPPEQDLIASTVAGVVTTVMGSSQPVVTRGTTDNLIPVYCSILAAVVVGLVAYIAFKRWNSCKQNKQGANSRPVNQTPPPEGEKLHSDSGISVDSQSLHDQQPHTQTASGQALKGDGGLYSSLPPAKREEVEKLLNGSAGDTWRHLAGELGYQPEHIDSFTHEACPVRALLASWATQDSATLDALLAALRRIQRADLVESLCSESTATSPV
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分子量
46.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The research on NGFR (nerve growth factor receptor), also known as TrkA (tropomyosin receptor kinase A), stems from its crucial role in neuronal development, survival, and differentiation. NGFR is a high-affinity receptor for nerve growth factor (NGF), a significant neurotrophic factor that promotes the growth and maintenance of sympathetic and sensory neurons. Dysregulation of NGFR signaling has been implicated in various neurodegenerative diseases, as well as in pain disorders, emphasizing the need for a deeper understanding of its molecular mechanisms. The recombinant production of NGFR proteins facilitates the exploration of its structural and functional properties, enabling researchers to investigate binding affinities with NGF and other ligands, assess signaling pathways activated upon receptor engagement, and develop potential therapeutic interventions. By producing NGFR in a recombinant system, scientists can achieve high yields of pure protein necessary for biophysical assays, crystallography, and functional studies. This research not only provides insights into NGFR's contribution to neuronal health but also paves the way for designing novel strategies to combat neurodegeneration and pain management through targeted modulation of NGFR activity.
