Analytical Data
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Gene name
PBX4
- Application
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Alternative Names
PBX4; Pre-B-cell leukemia transcription factor 4; Homeobox protein PBX4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BYU1
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Expression Region
1-374 aa
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AA Sequence
MAAPPRPAPS PPAPRRLDTS DVLQQIMAIT DQSLDEAQAR KHALNCHRMK PALFSVLCEI KEKTVVSIRG IQDEDPPDAQ LLRLDNMLLA EGVCRPEKRG RGGAVARAGT ATPGGCPNDN SIEHSDYRAK LSQIRQIYHS ELEKYEQACR EFTTHVTNLL QEQSRMRPVS PKEIERMVGA IHGKFSAIQM QLKQSTCEAV MTLRSRLLDA RRKRRNFSKQ ATEVLNEYFY SHLNNPYPSE EAKEELARKG GLTISQVSNW FGNKRIRYKK NMGKFQEEAT IYTGKTAVDT TEVGVPGNHA SCLSTPSSGS SGPFPLPSAG DAFLTLRTLA SLQPPPGGGC LQSQAQGSWQ GATPQPATAS PAGDPGSINS STSN
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Molecular Weight
40.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PBX4, a member of the PBX family of homeodomain transcription factors, plays a crucial role in various biological processes, including development, cellular differentiation, and oncogenesis. It functions by forming complexes with other transcription factors, which modulate gene expression and influence cellular pathways. Research has shown that PBX4 is involved in the regulation of various target genes, impacting hematopoiesis and the development of specific tissues. Abnormal expression or mutations in the PBX4 gene have been linked to several types of cancers, including leukemia and solid tumors, highlighting its potential as a therapeutic target. Studies investigating the structure and function of PBX4 protein, including its interactions with other proteins and DNA, are essential for understanding its role in tumorigenesis and normal physiological processes. Recent advancements in protein engineering and structural biology have enabled researchers to manipulate PBX4, paving the way for potential applications in targeted therapies and gene regulation strategies. Understanding the molecular mechanisms underlying PBX4 function may provide insights into novel treatment approaches for PBX4-related malignancies and further our knowledge of transcriptional regulation during development.
