Analytical Data
-
基因名
PARP6
- Application
-
别名
ADP-ribosyltransferase diphtheria toxin-like 17;ARTD17;Poly [ADP-ribose] polymerase 6;PARP-6
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q2NL67
-
表达区间
1-630 aa
-
氨基酸序列
MDIKGQFWNDDDSEGDNESEEFLYGVQGSCAADLYRHPQLDADIEAVKEIYSENSVSIREYGTIDDVDIDLHINISFLDEEVSTAWKVLRTEPIVLRLRFSLSQYLDGPEPSIEVFQPSNKEGFGLGLQLKKILGMFTSQQWKHLSNDFLKTQQEKRHSWFKASGTIKKFRAGLSIFSPIPKSPSFPIIQDSMLKGKLGVPELRVGRLMNRSISCTMKNPKVEVFGYPPSPQAGLLCPQHVGLPPPARTSPLVSGHCKNIPTLEYGFLVQIMKYAEQRIPTLNEYCVVCDEQHVFQNGSMLKPAVCTRELCVFSFYTLGVMSGAAEEVATGAEVVDLLVAMCRAALESPRKSIIFEPYPSVVDPTDPKTLAFNPKKKNYERLQKALDSVMSIREMTQGSYLEIKKQMDKLDPLAHPLLQWIISSNRSHIVKLPLSRLKFMHTSHQFLLLSSPPAKEARFRTAKKLYGSTFAFHGSHIENWHSILRNGLVNASYTKLQLHGAAYGKGIYLSPISSISFGYSGMGKGQHRMPSKDELVQRYNRMNTIPQTRSIQSRFLQSRNLNCIALCEVITSKDLQKHGNIWVCPVSDHVCTRFFFVYEDGQVGDANINTQDPKIQKEIMRVIGTQVYTN
-
分子量
78 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PARP6 (Poly (ADP-ribose) polymerase 6) is a member of the PARP family, known for its role in DNA damage repair and cellular responses to stress. Unlike its better-studied relatives, PARP1 and PARP2, which are primarily involved in poly(ADP-ribosyl)ation processes linked to DNA repair mechanisms, PARP6 has garnered attention for its unique functions and potential implications in various cellular pathways. Research indicates that PARP6 may play a role in regulating gene expression and modulating cellular signaling, suggesting a broader context in cell biology beyond DNA repair. Its involvement in neurodegenerative diseases and cancer pathology makes it a compelling target for therapeutic intervention. Moreover, the study of recombinant PARP6 proteins allows for detailed examination of its enzymatic activity, substrate interactions, and biological functions, thus aiding in elucidating the molecular mechanisms underlying its role in health and disease. Understanding PARP6's functional dynamics could provide insights into novel strategies for disease treatment and foster the development of targeted therapies aimed at mitigating the effects of its dysregulation in various pathophysiological contexts. Through advanced biotechnological approaches, such as recombinant protein expression and purification, researchers aim to decipher the precise mechanisms through which PARP6 influences cellular homeostasis, thereby contributing to a deeper understanding of its significance in molecular biology and potential applications in medicine.
