Analytical Data
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基因名
ARHGAP17
- Application
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别名
ARHGAP17；RICH1；Rho GTPase-activating Protein 17
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q68EM7
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表达区间
1-881aa
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氨基酸序列
MKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSICHHSHKRL VACFQGQHGTDAERRHKKLPLTALAQNMQEASTQLEDSLLGKMLETCGDA ENQLALELSQHEVFVEKEIVDPLYGIAEVEIPNIQKQRKQLARLVLDWDS VRARWNQAHKSSGTNFQGLPSKIDTLKEEMDEAGNKVEQCKDQLAADMYN FMAKEGEYGKFFVTLLEAQADYHRKALAVLEKTLPEMRAHQDKWAEKPAF GTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLK AALDCSTSHLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASV QDQDKKLQDLWRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIA IVLGPNLLWARNEGTLAEMAAATSVHVVAVIEPIIQHADWFFPEEVEFNV SEAFVPLTTPSSNHSFHTGNDSDSGTLERKRPASMAVMEGDLVKKESFGV KLMDFQAHRRGGTLNRKHISPAFQPPLPPTDGSTVVPAGPEPPPQSSRAE SSSGGGTVPSSAGILEQGPSPGDGSPPKPKDPVSAAVPAPGRNNSQIASG QNQPQAAAGSHQLSMGQPHNAAGPSPHTLRRAVKKPAPAPPKPGNPPPGH PGGQSSSGTSQHPPSLSPKPPTRSPSPPTQHTGQPPGQPSAPSQLSAPRR YSSSLSPIQAPNHPPPQPPTQATPLMHTKPNSQGPPNPMALPSEHGLEQP SHTPPQTPTPPSTPPLGKQNPSLPAPQTLAGGNPETAQPHAGTLPRPRPV PKPRNRPSVPPPPQPPGVHSAGDSSLTNTAPTASKIVTDSNSRVSEPHRS IFPEMHSDSASKDVPGRILLDIDNDTESTAL
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分子量
122 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ARHGAP17 (Rho GTPase-activating protein 17) plays a crucial role in regulating the Rho family of GTPases, which are pivotal in various cellular processes including cytoskeletal dynamics, cell proliferation, and migration. The dysregulation of Rho GTPases has been implicated in various diseases, particularly cancer, where altered cell signaling can lead to uncontrolled growth and metastasis. As a member of the RhoGAP family, ARHGAP17 influences RhoA and Rac1 pathways, thereby impacting actin filament organization and cellular adhesion. Research on ARHGAP17 has gained momentum due to its potential as a therapeutic target and biomarker in cancer progression. Understanding the structure and function of ARHGAP17 at the molecular level is essential for deciphering its role in cellular homeostasis and pathology. Experimental studies involving the expression and characterization of recombinant ARHGAP17 protein facilitate the exploration of its interactions, regulatory mechanisms, and effects on cell behavior. By elucidating these aspects, scientists aim to identify novel strategies for intervening in cancer and other Rho GTPase-related disorders, highlighting ARHGAP17's significance in biomedical research.
