Analytical Data
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基因名
PARP15
- Application
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别名
PARP15; BAL3; Protein mono-ADP-ribosyltransferase PARP15; EC 2.4.2.-; ADP-ribosyltransferase diphtheria toxin-like 7; ARTD7; B-aggressive lymphoma protein 3; Poly [ADP-ribose] polymerase 15; PARP-15
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q460N3
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表达区间
1-656 aa
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氨基酸序列
MHGVAGVTSR AGRDREAGSM LPAGNRGARK ASRRSSSRSM SRDNKFSKKD CLSIRNVVAS IQTKEGLNLK LISGDVLYIW ADVIVNSVPM NLQLGGGPLS RAFLQKAGPM LQKELDDRRR ETEEKVGNIF MTSGCNLDCK AVLHAVAPYW NNGAETSWQI MANIIKKCLT TVEVLSFSSI TFPMIGTGSL QFPKAVFAKL ILSEVFEYSS STRPITSPLQ EVHFLVYTND DEGCQAFLDE FTNWSRINPN KARIPMAGDT QGVVGTVSKP CFTAYEMKIG AITFQVATGD IATEQVDVIV NSTARTFNRK SGVSRAILEG AGQAVESECA VLAAQPHRDF IITPGGCLKC KIIIHVPGGK DVRKTVTSVL EECEQRKYTS VSLPAIGTGN AGKNPITVAD NIIDAIVDFS SQHSTPSLKT VKVVIFQPEL LNIFYDSMKK RDLSASLNFQ STFSMTTCNL PEHWTDMNHQ LFCMVQLEPG QSEYNTIKDK FTRTCSSYAI EKIERIQNAF LWQSYQVKKR QMDIKNDHKN NERLLFHGTD ADSVPYVNQH GFNRSCAGKN AVSYGKGTYF AVDASYSAKD TYSKPDSNGR KHMYVVRVLT GVFTKGRAGL VTPPPKNPHN PTDLFDSVTN NTRSPKLFVV FFDNQAYPEY LITFTA
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分子量
74.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
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Protein Description
PARP15, also known as ARTD8, is a member of the Poly(ADP-ribose) polymerase (PARP) family, which plays a critical role in various cellular processes, including DNA repair, gene regulation, and cellular stress responses. Research into PARP15 has gained momentum due to its involvement in the modulation of immune responses and its potential link to cancer progression. Unlike other PARP family members, PARP15 has unique functions, such as mediating the poly(ADP-ribosyl)ation of target proteins, which influences protein interactions and cellular signaling pathways. Studies have shown that PARP15 is implicated in the regulation of tumor necrosis factor (TNF) signaling, suggesting its relevance in inflammation and autoimmunity. Furthermore, PARP15 has been found to have an intricate relationship with viral infections, highlighting its role in antiviral immunity. The development of PARP inhibitors, initially aimed at other PARP family members, raises questions about PARP15's potential as a therapeutic target. Understanding the enzymatic activity, substrate specificity, and regulatory mechanisms of PARP15 is essential for uncovering its biological roles and therapeutic implications. As research continues, PARP15 may emerge as a critical player in cancer therapy and immune modulation, offering new avenues for clinical applications.
