Analytical Data
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基因名
P2RX5
- Application
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别名
P2RX5；P2X5；P2X5FL；P2X purinoceptor 5
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q93086
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表达区间
1-444aa
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氨基酸序列
MGQAGCKGLCLSLFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVDTSLQSAVITKVKGVAFTNTSDLGQRIWDVADYVIPAQGENVFFVVTNLIVTPNQRQNVCAENEGIPDGACSKDSDCHAGEAVTAGNGVKTGRCLRRENLARGTCEIFAWCPLETSSRPEEPFLKEAEDFTIFIKNHIRFPKFNFSKSNVMDVKDRSFLKSCHFGPKNHYCPIFRLGSVIRWAGSDFQDIALEGGVIGINIEWNCDLDKAASECHPHYSFSRLDNKLSKSVSSGYNFRFARYYRDAAGVEFRTLMKAYGIRFDVMVNGKAGKFSIIPTIINVGSGVALMGAGAFFCDLVLIYLIKKREFYRDKKYEEVRGLEDSSQEAEDEASGLGLSEQLTSGPGLLGMPEQQELQEPPEAKRGSSSQKGNGSVCPQLLEPHRST
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分子量
49.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
P2RX5, a member of the P2X receptor family, is an ATP-gated ion channel that plays a critical role in various physiological processes, including neurotransmission, inflammation, and cell proliferation. Research has indicated that P2RX5 is involved in painful neuropathic conditions, making it a potential therapeutic target for pain management. The receptor's activation leads to the influx of cations, predominantly calcium ions, which subsequently triggers downstream signaling pathways. Understanding the structure and function of P2RX5 is essential, as it could unveil novel mechanisms of disease and provide insights into designing targeted drugs. Recent advances in recombinant protein technology allow for the expression and purification of P2RX5, facilitating detailed biochemical and pharmacological studies. This research is particularly important in the context of studying receptor-ligand interactions and exploring the receptor's role in different cellular contexts. By elucidating the signaling pathways and functional mechanisms associated with P2RX5, scientists aim to develop innovative strategies for treating conditions related to its dysregulation. Overall, the investigation of P2RX5 recombinant protein represents a promising avenue for both basic science and translational research, particularly in the field of pain management and neurological disorders.
