Analytical Data
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Gene name
PAK1IP1
- Application
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Alternative Names
PAK1IP1; PIP1; WDR84; p21-activated protein kinase-interacting protein 1; PAK/PLC-interacting protein 1; hPIP1; PAK1-interacting protein 1; WD repeat-containing protein 84
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NWT1
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Expression Region
1-392 aa
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AA Sequence
MELVAGCYEQ VLFGFAVHPE PEACGDHEQW TLVADFTHHA HTASLSAVAV NSRFVVTGSK DETIHIYDMK KKIEHGALVH HSGTITCLKF YGNRHLISGA EDGLICIWDA KKWECLKSIK AHKGQVTFLS IHPSGKLALS VGTDKTLRTW NLVEGRSAFI KNIKQNAHIV EWSPRGEQYV VIIQNKIDIY QLDTASISGT ITNEKRISSV KFLSESVLAV AGDEEVIRFF DCDSLVCLCE FKAHENRVKD MFSFEIPEHH VIVSASSDGF IKMWKLKQDK KVPPSLLCEI NTNARLTCLG VWLDKVADMK ESLPPAAEPS PVSKEQSKIG KKEPGDTVHK EEKRSKPNTK KRGLTGDSKK ATKESGLIST KKRKMVEMLE KKRKKKKIKT MQ
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Molecular Weight
43.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PAK1IP1, or p21-activated kinase 1 interacting protein 1, has garnered increasing attention in the field of molecular biology due to its involvement in critical cellular processes, including cell migration, proliferation, and apoptosis. Initially identified as a potential regulator of PAK1, a serine/threonine kinase implicated in various signaling pathways, PAK1IP1 has been shown to influence cytoskeletal dynamics and cellular stress responses. Research suggests that PAK1IP1 may play a role in cancer progression, particularly through its interactions with oncogenic pathways and its modulation of protein-protein interactions. Furthermore, studies indicate that PAK1IP1 could be implicated in neurological disorders, where alterations in its expression or function may contribute to pathophysiological conditions. Given its significant roles in these diverse biological contexts, the production and study of recombinant PAK1IP1 protein have become essential for elucidating its mechanistic pathways and potential as a therapeutic target. Advances in recombinant DNA technology facilitate the expression and purification of this protein, allowing for detailed biochemical assays and functional studies. These investigations are crucial to understanding how PAK1IP1 modulates key signaling cascades and how it may be leveraged for novel therapeutic strategies in diseases where its dysregulation is implicated. As research continues, PAK1IP1 may emerge as a critical player in the development of targeted therapies, underscoring the importance of recombinant protein studies in advancing our knowledge of cellular regulation mechanisms.
