Analytical Data
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基因名
ARHGEF3
- Application
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别名
ARHGEF3; Rho guanine nucleotide exchange factor 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NR81
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表达区间
1-526aa
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氨基酸序列
MVAKDYPFYL TVKRANCSLE LPPASGPAKD AEEPSNKRVK PLSRVTSLAN LIPPVKATPL KRFSQTLQRS ISFRSESRPD ILAPRPWSRN AAPSSTKRRD SKLWSETFDV CVNQMLTSKE IKRQEAIFEL SQGEEDLIED LKLAKKAYHD PMLKLSIMTE QELNQIFGTL DSLIPLHEEL LSQLRDVRKP DGSTEHVGPI LVGWLPCLSS YDSYCSNQVA AKALLDHKKQ DHRVQDFLQR CLESPFSRKL DLWNFLDIPR SRLVKYPLLL REILRHTPND NPDQQHLEEA INIIQGIVAE INTKTGESEC RYYKERLLYL EEGQKDSLID SSRVLCCHGE LKNNRGVKLH VFLFQEVLVI TRAVTHNEQL CYQLYRQPIP VKDLLLEDLQ DGEVRLGGSL RGAFSNNERI KNFFRVSFKN GSQSQTHSLQ ANDTFNKQQW LNCIRQAKET VLCAAGQAGV LDSEGSFLN
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分子量
59 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ARHGEF3, also known as Rac/Cdc42 guanine nucleotide exchange factor 3, is a member of the RhoGEF family and plays a crucial role in cellular signaling pathways by activating Rho GTPases, which are essential for various cellular processes including cytoskeletal dynamics, cell migration, and proliferation. The study of recombinant ARHGEF3 protein is significant due to its involvement in a range of biological functions and its implications in various diseases, particularly cancer, where aberrant signaling can lead to increased cell invasion and metastasis. Understanding the molecular mechanisms of ARHGEF3 can provide insights into its role in oncogenesis and may reveal potential therapeutic targets. Moreover, recombinant ARHGEF3 protein can be utilized in biochemical and structural studies to elucidate its function and interaction with other molecules. Such research can also explore the protein's regulatory mechanisms and its therapeutic potential in modulating Rho GTPase activity. Overall, ARHGEF3 serves as a vital component in the signaling networks that govern cell behavior, making its study essential for advancing our understanding of cellular physiology and pathology.
