Analytical Data
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基因名
TPX
- Application
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别名
TPX；Targeting Protein for Xklp2
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种属
E.coli
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P0A862
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表达区间
1-168aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMSQTVHFQGNPVTVANSIPQAGSKAQTFTL VAKDLSDVTLGQFAGKRKVLNIFPSIDTGVCAASVRKFNQLATEIDNTVV LCISADLPFAQSRFCGAEGLNNVITLSTFRNAEFLQAYGVAIADGPLKGL AARAVVVIDENDNVIFSQLVDEITTEPDYEAALAVLKA
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分子量
20 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TPX (targeting protein for Xklp2) is a crucial co-factor that plays a significant role in the process of microtubule nucleation and stabilization during cell division. It is primarily involved in the assembly of the mitotic spindle, which is essential for accurate chromosome segregation. Research into TPX has gained increasing attention due to its implications in cancer biology, as aberrations in its function can lead to chromosomal instability and tumorigenesis. Its interaction with the motor protein Xklp2 highlights a complex regulatory mechanism that is fundamental for maintaining proper cell cycle dynamics. Understanding TPX's structural properties and its interactions at the molecular level may provide insights into novel therapeutic targets for cancer treatment. Additionally, TPX has emerged as a potential biomarker for certain cancer types, further emphasizing the need for comprehensive studies on its behavior and regulatory mechanisms in various cellular contexts. The ongoing research aims to elucidate the precise molecular pathways involving TPX, which could pave the way for innovative strategies in cancer therapy and improve our understanding of microtubule dynamics in cellular processes.
