Analytical Data
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Gene name
PAIP2B
- Application
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Alternative Names
Kiaa1155; PABP-interacting protein 2B; PAI2B_HUMAN; PAIP-2B; Paip2b; Poly(A) binding protein interacting protein 2B; Poly(A)-binding protein-interacting protein 2B; Polyadenylate-binding protein-interacting protein 2B
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9ULR5
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Expression Region
1-123 aa
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AA Sequence
MNGSNMANTS PSVKSKEDQG LSGHDEKENP FAEYMWMENE EDFNRQVEEE LQEQDFLDRC FQEMLDEEDQ DWFIPSRDLP QAMGQLQQQL NGLSVSEGHD SEDILSKSNL NPDAKEFIPG EKY
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Molecular Weight
14.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PAIP2B (Poly(A)-binding protein interacting protein 2B) is a crucial regulatory protein involved in the maturation and translation of mRNA. It is part of the PAIP family, which plays a significant role in modulating the functions of poly(A)-binding proteins, particularly in promoting translation and stabilizing mRNA. Research has shown that PAIP2B interacts with various components of the translation machinery, influencing the efficiency of protein synthesis in cells. Understanding the role of PAIP2B is particularly important in the context of cancer and other diseases, where dysregulation of translation can lead to uncontrolled cell growth and proliferation. Additionally, PAIP2B is involved in several cellular processes, including cellular stress responses and the regulation of specific mRNA targets, making it a potential biomarker or therapeutic target. Recent studies have focused on the structural characteristics and functional mechanisms of PAIP2B, shedding light on its complex interactions within the cell. Investigating the molecular pathways affected by PAIP2B can provide insights into its potential role in disease pathology and pave the way for novel therapeutic strategies that target translation regulation in various diseases, particularly in cancers where translation control is often altered. Thus, ongoing research on PAIP2B, including its recombinant protein studies, is pivotal for unraveling its biological significance and therapeutic potential.
