Analytical Data
-
Gene name
PACSIN3
- Application
-
Alternative Names
Endophilin 1; Endophilin I; FLJ17861; OTTHUMP00000234262; OTTHUMP00000234263; OTTHUMP00000234264; PACN3_HUMAN; Pacsin3; Protein kinase C and casein kinase substrate in neurons 3; Protein kinase C and casein kinase substrate in neurons protein 3; SDPIII; SH3 domain containing protein 6511; SH3 domain-containing protein 6511; syndapin III
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q9UKS6
-
Expression Region
1-424 aa
-
AA Sequence
MAPEEDAGGE ALGGSFWEAG NYRRTVQRVE DGHRLCGDLV SCFQERARIE KAYAQQLADW ARKWRGTVEK GPQYGTLEKA WHAFFTAAER LSALHLEVRE KLQGQDSERV RAWQRGAFHR PVLGGFRESR AAEDGFRKAQ KPWLKRLKEV EASKKSYHAA RKDEKTAQTR ESHAKADSAV SQEQLRKLQE RVERCAKEAE KTKAQYEQTL AELHRYTPRY MEDMEQAFET CQAAERQRLL FFKDMLLTLH QHLDLSSSEK FHELHRDLHQ GIEAASDEED LRWWRSTHGP GMAMNWPQFE EWSLDTQRTI SRKEKGGRSP DEVTLTSIVP TRDGTAPPPQ SPGSPGTGQD EEWSDEESPR KAATGVRVRA LYDYAGQEAD ELSFRAGEEL LKMSEEDEQG WCQGQLQSGR IGLYPANYVE CVGA
-
Molecular Weight
48.4 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The PACSIN3 protein, a member of the PACSIN family, plays a crucial role in cellular processes such as endocytosis, membrane trafficking, and cytoskeletal dynamics. Research has highlighted its involvement in lipid metabolism and synaptic function, making it a significant factor in neuronal health and disease. The interest in PACSIN3 has escalated due to its potential link to neurodegenerative disorders, such as Alzheimer's disease, where disturbances in endocytosis and synaptic activity are observed. Recent studies have also suggested that PACSIN3 may interact with various signaling pathways, influencing cell migration and proliferation. Understanding the structure and function of PACSIN3 is vital for elucidating its role in cellular mechanisms and its implications in disease. Consequently, the characterization of PACSIN3 through recombinant protein expression is an essential step toward discovering its biochemical properties, functional interactions, and therapeutic potential in various neurological and metabolic conditions. This approach not only aids in the delineation of its biological functions but also facilitates the development of targeted therapeutic strategies that could manipulate PACSIN3 activity to restore normal cellular functions in pathological states. With ongoing research, PACSIN3 is emerging as a promising candidate for further exploration in the context of neurobiology and disease management.
