Analytical Data
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基因名
ACSS1
- Application
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别名
ACSS1；SIR2L3；NAD-dependent Protein deacetylase sirtuin-3. mitochondrial
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NUB1
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表达区间
38-689aa
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氨基酸序列
ASGPSGSAPAVAAAAAQPGSYPALSAQAAREPAAFWGPLARDTLVWDTPY HTVWDCDFSTGKIGWFLGGQLNVSVNCLDQHVRKSPESVALIWERDEPGT EVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVAAMLACAR IGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDE AVKHCPTVQHVLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPESMGSED MLFMLYTSGSTGMPKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADI GWITGHSYVVYGPLCNGATSVLFESTPVYPNAGRYWETVERLKINQFYGA PTAVRLLLKYGDAWVKKYDRSSLRTLGSVGEPINCEAWEWLHRVVGDSRC TLVDTWWQTETGGICIAPRPSEEGAEILPAMAMRPFFGIVPVLMDEKGSV VEGSNVSGALCISQAWPGMARTIYGDHQRFVDAYFKAYPGYYFTGDGAYR TEGGYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAVIGYPHDI KGEAAFAFIVVKDSAGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPK TRSGKVMRRLLRKIITSEAQELGDTTTLEDPSIIAEILSVYQKCKDKQAA AK
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分子量
75 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ACSS1 (Acetyl-CoA synthetase 1) is an enzyme that plays a critical role in cellular metabolism by catalyzing the conversion of acetate into acetyl-CoA, a central metabolic intermediate linked to various biosynthetic pathways and energy production. The research on ACSS1 has gained momentum due to its involvement in several physiological processes and its potential implications in various diseases, including cancer, metabolic disorders, and neurodegenerative conditions. Abnormal regulation of ACSS1 has been associated with altered cellular homeostasis, influencing lipid metabolism, and tumor progression. Recent studies have revealed that ACSS1 is not only pivotal for maintaining cellular energy levels but also plays a significant role in modulating gene expression through acetylation mechanisms. The enzyme's activity can be influenced by metabolic cues, revealing a complex interplay between metabolism and epigenetic regulation. As the understanding of ACSS1's role in health and disease expands, it presents a promising target for therapeutic interventions aimed at modulating metabolic pathways. Consequently, ongoing research efforts are focused on elucidating the molecular mechanisms governing ACSS1 function, its regulation under various metabolic states, and its potential as a biomarker or therapeutic target in metabolic diseases and cancers.
