Analytical Data
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基因名
ARFGAP3
- Application
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别名
ADP ribosylation factor GTPase activating Protein 1; ADP ribosylation factor GTPase activating Protein 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NP61
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表达区间
1-516aa
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氨基酸序列
MGDPSKQDIL TIFKRLRSVP TNKVCFDCGA KNPSWASITY GVFLCIDCSG SHRSLGVHLS FIRSTELDSN WSWFQLRCMQ VGGNASASSF FHQHGCSTND TNAKYNSRAA QLYREKIKSL ASQATRKHGT DLWLDSCVVP PLSPPPKEED FFASHVSPEV SDTAWASAIA EPSSLTSRPV ETTLENNEGG QEQGPSVEGL NVPTKATLEV SSIIKKKPNQ AKKGLGAKKG SLGAQKLANT CFNEIEKQAQ AADKMKEQED LAKVVSKEES IVSSLRLAYK DLEIQMKKDE KMNISGKKNV DSDRLGMGFG NCRSVISHSV TSDMQTIEQE SPIMAKPRKK YNDDSDDSYF TSSSSYFDEP VELRSSSFSS WDDSSDSYWK KETSKDTETV LKTTGYSDRP TARRKPDYEP VENTDEAQKK FGNVKAISSD MYFGRQSQAD YETRARLERL SASSSISSAD LFEEPRKQPA GNYSLSSVLP NAPDMAQFKQ GVRSVAGKLS VFANGVVTSI QDRYGS
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分子量
56.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ARFGAP3, a member of the Arf GTPase-activating protein (GAP) family, plays a crucial role in regulating the activity of ADP-ribosylation factors (ARFs), which are vital for membrane traffic and cytoskeletal dynamics. Research has demonstrated that ARFGAP3 is involved in various cellular processes, including endocytosis, exocytosis, and the formation of vesicles. Dysregulation of ARFGAP3 has been implicated in several diseases, including cancer, where it may contribute to altered endocytic pathways and tumor progression. The study of ARFGAP3 recombinant proteins has gained significant attention in recent years due to their potential applications in understanding the molecular mechanisms of these pathways. By producing ARFGAP3 as a recombinant protein, researchers can investigate its structural properties, enzymatic activity, and interactions with other cellular components, thus providing insights into its functional roles in normal and pathological states. Furthermore, understanding the mechanisms by which ARFGAP3 regulates ARF activity may reveal novel therapeutic targets for diseases associated with its dysfunction. Therefore, the exploration of ARFGAP3 recombinant proteins is not only essential for basic cellular biology but also for advancing therapeutic strategies against related diseases.
