Analytical Data
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基因名
ARFGAP2
- Application
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别名
ARFG2_HUMAN; ARFGAP2; FLJ14576; FLJ26000
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8N6H7
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表达区间
2-521aa
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氨基酸序列
AAEPNKTEI QTLFKRLRAV PTNKACFDCG AKNPSWASIT YGVFLCIDCS GVHRSLGVHL SFIRSTELDS NWNWFQLRCM QVGGNANATA FFRQHGCTAN DANTKYNSRA AQMYREKIRQ LGSAALARHG TDLWIDNMSS AVPNHSPEKK DSDFFTEHTQ PPAWDAPATE PSGTQQPAPS TESSGLAQPE HGPNTDLLGT SPKASLELKS SIIGKKKPAA AKKGLGAKKG LGAQKVSSQS FSEIERQAQV AEKLREQQAA DAKKQAEESM VASMRLAYQE LQIDRKKEEK KLQNLEGKKR EQAERLGMGL VSRSSVSHSV LSEMQVIEQE TPVSAKSSRS QLDLFDDVGT FASGPPKYKD NPFSLGESFG SRWDTDAAWG MDRVEEKEPE VTISSIRPIS ERATNRREVE SRSSGLESSE ARQKFAGAKA ISSDMFFGRE VDAEYEARSR LQQLSGSSAI SSSDLFGDMD GAHGAGSVSL GNVLPTADIA QFKQGVKSVA GKMAVLANGV MNSLQDRYGS Y
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分子量
56.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ARFGAP2 (ADP-ribosylation factor GTPase-activating protein 2) is a key regulator of intracellular membrane traffic and is involved in the recycling and transport of vesicles between various cellular compartments. It plays a critical role in modulating the activity of ADP-ribosylation factors (ARFs), which are essential for the formation, motility, and fusion of transport vesicles. Dysregulation of ARFGAP2 has been implicated in several pathological conditions, including cancer and neurodegenerative diseases, thereby underscoring its significance in cellular homeostasis and disease mechanisms. Recent studies have focused on the structural biology of ARFGAP2 and its interaction with ARF proteins, revealing insights into the molecular mechanisms underlying its function. Understanding the biochemical properties and pathways involving ARFGAP2 can provide valuable perspectives for developing therapeutic strategies targeting related diseases. Given its essential role in cellular trafficking, researchers are increasingly exploring ARFGAP2 as a potential biomarker and therapeutic target, which positions it at the forefront of cell biology and molecular medicine research.
