Analytical Data
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基因名
TNNC1
- Application
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别名
TNNC1；TNNC；Troponin C. slow skeletal and cardiac muscles
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P63316
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表达区间
1-161aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMDDIYKAAVEQLTEEQKNEFKAAFDIFVLG AEDGCISTKELGKVMRMLGQNPTPEELQEMIDEVDEDGSGTVDFDEFLVM MVRCMKDDSKGKSEEELSDLFRMFDKNADGYIDLDELKIMLQATGETITE DDIEELMKDGDKNNDGRIDYDEFLEFMKGVE
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分子量
21 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The TNNC1 gene encodes the troponin C protein, a crucial component of the cardiac and skeletal muscle contraction apparatus. Research on TNNC1 recombinant protein is driven by its significant role in muscle physiology and its implications in various myopathies and heart diseases. Troponin C binds calcium ions, facilitating the conformational changes necessary for muscle contraction. Mutations in TNNC1 have been linked to familial hypertrophic cardiomyopathy (HCM), which can lead to severe cardiac conditions. The study of recombinant TNNC1 protein allows researchers to better understand the structure-function relationships of this protein, investigate the molecular mechanisms underlying muscle contraction, and explore potential therapeutic interventions for muscle-related diseases. Additionally, recombinant TNNC1 can be used in biochemical assays to study its interactions with other proteins in the troponin complex, providing insights into how alterations in its function can lead to pathological conditions. Understanding the intricate workings of TNNC1 is essential for the development of targeted therapies for patients suffering from cardiac and skeletal muscle disorders. As such, the exploration of TNNC1 recombinant protein has become an important focus in cardiovascular research, with the potential to pave the way for novel diagnostic tools and treatments.
