Analytical Data
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基因名
TNFSF13
- Application
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别名
TNFSF13；APRIL；Tumor necrosis factor ligand superfamily member 13
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O75888
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表达区间
105-250aa
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氨基酸序列
AVLTQKQKKQ HSVLHLVPIN ATSKDDSDVT VMWQPALRR GRGLQAQGYG VRIQDAGVYL LYSQVLFQDV TFTMGQVVSR EGQGRQETLF CIRSMPSHP DRAYNSCYSA GVFHLHQGDI LSVIIPRARA KLNLSPHGTF LGFVKL
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分子量
20 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TNFSF13, also known as B-cell activating factor (BAFF), is a member of the tumor necrosis factor (TNF) superfamily that plays a critical role in B-cell survival, proliferation, and differentiation. Its significance in the immune system has garnered substantial research interest, particularly in understanding autoimmune diseases and lymphoid malignancies. Dysregulation of TNFSF13 has been implicated in various pathologies, including systemic lupus erythematosus (SLE) and multiple myeloma, where elevated levels of BAFF contribute to excessive B-cell activation and survival. Researchers have focused on the recombinant production of TNFSF13 to explore its structural properties, receptor interactions, and biological functions. This recombinant protein serves as a valuable tool in elucidating the underlying mechanisms of B-cell biology and the potential therapeutic avenues for targeting BAFF in autoimmune disorders. Furthermore, the generation of monoclonal antibodies against TNFSF13 has shown promise in treating conditions associated with its overexpression. Consequently, the study of TNFSF13 recombinant protein not only advances our fundamental understanding of immune regulation but also paves the way for innovative strategies to modulate immune responses in clinical settings.
