Analytical Data
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Gene name
TNFRSF10C
- Application
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Alternative Names
TNFRSF10C；DCR1；Tumor necrosis factor receptor superfamily member 10C
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O14798
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Expression Region
26-236aa
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AA Sequence
ATTAR QEEVPQQTVA PQQQRHSFKG EECPAGSHRS EHTGACNPCT EGVDYTNASN NEPSCFPCTV CKSDQKHKSS CTMTRDTVCQ CKEGTFRNEN SPEMCRKCSR CPSGEVQVSN CTSWDDIQCV EEFGANATVE TPAAEETMNT SPGTPAPAAE ETMNTSPGTP APAAEETMTT SPGTPAPAAE ETMTTSPGTP APAAEETMIT SPGTPA
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TNFRSF10C, also known as the "decoy receptor" for tumor necrosis factor (TNF), has garnered significant interest in cancer and immune regulation research due to its role in modulating apoptosis and inflammatory responses. This receptor, part of the TNF receptor superfamily, primarily interacts with TNF-related apoptosis-inducing ligand (TRAIL) and is known to inhibit TRAIL-mediated apoptosis in various cell types. The expression of TNFRSF10C is often upregulated in certain tumors, suggesting its potential role in tumor immune evasion. Researchers have been focusing on the development of recombinant TNFRSF10C proteins to better understand their functional mechanisms and explore therapeutic applications. By creating and studying these recombinant forms, researchers aim to investigate how TNFRSF10C influences immune cell behavior, tumor growth, and interaction with other immune regulatory pathways. These insights could lead to novel strategies for enhancing anti-tumor immunity or treating autoimmune diseases by modulating the receptor's activity. Additionally, recombinant TNFRSF10C proteins are being explored as potential biomarker candidates for cancer prognosis and therapy response, given their involvement in the tumor microenvironment. The ongoing research holds promise for elucidating the complex roles of TNFRSF10C in cancer biology and its potential as a target for innovative therapeutic interventions.
