Analytical Data
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基因名
APCDD1
- Application
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别名
Adenomatosis polyposis coli down-regulated 1 Protein; APCD1_HUMAN; APCDD 1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8J025
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表达区间
1-514aa
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氨基酸序列
MSWPRRLLLRYLFPALLLHGLGEGSALLHPDSRSHPRSLEKSAWRAFKESQCHHMLKHLHNGARITVQMPPTIEGHWVSTGCEVRSGPEFITRSYRFYHNNTFKAYQFYYGSNRCTNPTYTLIIRGKIRLRQASWIIRGGTEADYQLHNVQVICHTEAVAEKLGQQVNRTCPGFLADGGPWVQDVAYDLWREENGCECTKAVNFAMHELQLIRVEKQYLHHNLDHLVEELFLGDIHTDATQRMFYRPSSYQPPLQNAKNHDHACIACRIIYRSDEHHPPILPPKADLTIGLHGEWVSQRCEVRPEVLFLTRHFIFHDNNNTWEGHYYHYSDPVCKHPTFSIYARGRYSRGVLSSRVMGGTEFVFKVNHMKVTPMDAATASLLNVFNGNECGAEGSWQVGIQQDVTHTNGCVALGIKLPHTEYEIFKMEQDARGRYLLFNGQRPSDGSSPDRPEKRATSYQMPLVQCASSSPRAEDLAEDSGSSLYGRAPGRHTWSLLLAALACLVPLLHWNIRR
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分子量
85.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
APCDD1, also known as antagonistic to beta-catenin and TCF-4, is a critical protein implicated in the regulation of Wnt signaling pathways, which play a vital role in cellular processes such as proliferation, differentiation, and apoptosis. Dysregulation of Wnt signaling is frequently associated with various cancers and developmental disorders, making APCDD1 a potential therapeutic target. Studies show that APCDD1 acts as a negative regulator of the β-catenin/TCF pathway, thereby influencing tumorigenesis by modulating gene expression linked to cell growth and migration. The recombinant production of APCDD1 has garnered interest as it allows for detailed investigations into its structural and functional roles. Characterizing the protein’s interactions and regulatory mechanisms could enhance the understanding of its biological functions and pave the way for novel therapeutic interventions in Wnt-related diseases. Moreover, producing APCDD1 as a recombinant protein provides a platform for high-throughput screenings and functional assays, facilitating the discovery of small molecules that might modulate its activity, ultimately leading to innovative strategies in cancer therapy and regenerative medicine. Consequently, the study of recombinant APCDD1 not only holds promise for elucidating the complexities of cellular signaling networks but also positions this protein as a notable candidate for future biomedical applications.
