Analytical Data
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Gene name
SREK1
- Application
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Alternative Names
SREK1；SFRS12；SRRP86；Splicing regulatory glutamine/lysine-rich Protein 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BRV8
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Expression Region
1-207aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMSCTIEK ILTDAKTLLE RLREHDAAAE SLVDQSAALH RRVAAMREAG TALPDQYQED ASDMKDMSKY KPHILLSQEN TQIRDLQQEN RELWISLEEH QDALELIMSK YRKQMLQLMV AKKAVDAEPV LKAHQSHSAE IESQIDRICE MGEVMRKAVQ VDDDQFCKIQ EKLAQLELEN KELRELLSIS SESLQARKEN SMDTASQAIK
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Molecular Weight
26 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SREK1, or SREK1 (Suppressor of Ras Efferent Kinase 1), is a protein that plays a critical role in cellular signaling pathways, particularly in relation to cancer and cellular stress responses. Research has shown that SREK1 is involved in modulating various physiological processes, including cell proliferation, differentiation, and apoptosis. As a member of the Ras signaling pathway, SREK1 acts as a key regulator that can influence the tumorigenic potential of cells by interacting with other signaling molecules and transcription factors. Its expression levels have been linked to multiple cancers, highlighting its potential as a biomarker for cancer diagnosis and prognosis. Recent studies have focused on the recombinant expression of SREK1 to understand its structural and functional properties better, paving the way for therapeutic interventions. The production of recombinant SREK1 allows for in-depth investigations into its mechanistic roles in disease pathways, offering insights into how targeted therapies could be developed for malignancies where SREK1 is dysregulated. Exploring the biophysical characteristics of SREK1, alongside its association with other signal transduction proteins, could also lead to novel strategies for combating cancer and improving therapeutic efficacy. Overall, ongoing research into SREK1 recombinant protein not only enhances our understanding of intracellular signaling networks but also presents promising avenues for innovative cancer treatment options.
