Analytical Data
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Gene name
ANKS3
- Application
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Alternative Names
ANKS3; KIAA1977Ankyrin repeat and SAM domain-containing Protein 3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6ZW76
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Expression Region
1-656aa
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AA Sequence
MSELSDEASE PELLNRSLSM WHGLGTQVSG EELDVPLDLH TAASIGQYEV VKECVQRREL DLNKKNGGGW TPLMYASYIG HDTIVHLLLE AGVSVNVPTP EGQTPLMLAS SCGNESIAYF LLQQGAELEM KDIQGWTALF HCTSAGHQHM VRFLLDSGAN ANVREPICGF TPLMEAAAAG HEIIVQYFLN HGVKVDARDH SGATARMLAK QYGHMKIVAL MDTYSPSLPK SLYRSPEKYE DLSSSDESCP APQRQRPCRK KGVSIHEGPR ALARITGIGL GGRAPRPRYE QAPPRGYVTF NSSGENPLEE EGLCCRDVTS PINERDVESS SSSSSREEHA FCANLGPVQS SSSSEGLARA QGLSSEASVE SNEDSDHACK SSARKQAKSY MKTKNPDSQW PPRAATDREG FLAESSPQTQ RAPYSGPQDL AALLEQIGCL KYLQVFEEQD VDLRIFLTLT ESDLKEIGIT LFGPKRKMTS AIARWHSSAR PPGDALELAY ADRLEAEMQE LAIQLHKRCE EVEATRGQVC QEQELRAVVE SCLLEQDRAR EDLQARLRET WALARDAALV LDQLRACQAE LSSRVRQDQP PGAATLGLAV PPADSKGWQA SLQAMSLPEL SGALEDRVRE MGQALCLVTQ SLEKLQVLNG KKWRET
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Molecular Weight
656 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ANKS3, or Ankyrin Repeat and SAM Domain Containing 3, is a protein that plays a crucial role in various cellular processes, including signal transduction, cell cycle regulation, and the maintenance of cellular integrity. Its unique structure, characterized by ankyrin repeats and a SAM (Sterile Alpha Motif) domain, enables it to interact with multiple protein partners, suggesting its involvement in diverse biological pathways. Recent studies have highlighted its significance in the context of various diseases, including cancer, where aberrant expression of ANKS3 has been linked to altered cellular signaling and proliferation. Furthermore, research has indicated that ANKS3 may play a role in neurodegenerative disorders and immune responses, underscoring its potential as a therapeutic target. The recombinant expression of ANKS3 enables detailed biochemical and biophysical characterization, which is vital for understanding its function and interaction mechanisms. By producing ANKS3 in a recombinant system, researchers can investigate its structural properties, elucidate its binding partners, and assess its functional roles in disease models. This research not only contributes to the fundamental understanding of ANKS3 but also opens avenues for potential interventions in pathologies associated with its dysregulation. As the field progresses, the exploration of ANKS3 through recombinant techniques may pave the way for innovative therapeutic strategies aimed at modulating its activity in various disease contexts.
