Analytical Data
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基因名
TGM2
- Application
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别名
TGM2；Protein-glutamine gamma-glutamyltransferase 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P21980
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表达区间
1-548aa
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氨基酸序列
MAEELVLERCDLELETNGRDHHTADLCREKLVVRRGQPFWLTLHFEGRNY EASVDSLTFSVVTGPAPSQEAGTKARFPLRDAVEEGDWTATVVDQQDCTL SLQLTTPANAPIGLYRLSLEASTGYQGSSFVLGHFILLFNAWCPADAVYL DSEEERQEYVLTQQGFIYQGSAKFIKNIPWNFGQFEDGILDICLILLDVN PKFLKNAGRDCSRRSSPVYVGRVVSGMVNCNDDQGVLLGRWDNNYGDGVS PMSWIGSVDILRRWKNHGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTN YNSAHDQNSNLLIEYFRNEFGEIQGDKSEMIWNFHCWVESWMTRPDLQPG YEGWQALDPTPQEKSEGTYCCGPVPVRAIKEGDLSTKYDAPFVFAEVNAD VVDWIQQDDGSVHKSINRSLIVGLKISTKSVGRDEREDITHTYKYPEGSS EEREAFTRANHLNKLAEKEETGMAMRIRVGQSMNMGSDFDVFAHITNNTA EEYVCRLLLCARTVSYNGILGPECGTKYLLNLNLEPFSGKALCSWSIC
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分子量
88 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Transglutaminase 2 (TGM2) is an important enzyme that plays diverse roles in various biological processes, including protein crosslinking, cell adhesion, and apoptosis. Research on TGM2 has gained momentum due to its implications in numerous pathologies, including neurodegenerative diseases, cancer, and cardiovascular disorders. Specifically, TGM2 has been implicated in the development of Alzheimer's disease, where it contributes to amyloid plaque formation and neuronal apoptosis. Furthermore, its overexpression in certain cancers has been associated with enhanced cell survival and tumor progression. Consequently, understanding the functional properties and regulatory mechanisms of TGM2 is crucial for developing targeted therapeutic strategies. Recombinant TGM2 protein studies have facilitated insights into its biochemical activities, substrate specificity, and potential as a biomarker for disease. The generation of recombinant TGM2 allows for controlled experimental conditions and the ability to manipulate the enzyme for functional assays, providing a clearer picture of its role in health and disease. As researchers continue to investigate TGM2's multifaceted roles, the potential for its application in diagnostics and therapeutics remains a significant area of interest.
