Analytical Data
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Gene name
TGM2
- Application
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Alternative Names
TGM2；Protein-glutamine gamma-glutamyltransferase 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P21980
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Expression Region
1-548aa
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AA Sequence
MAEELVLERCDLELETNGRDHHTADLCREKLVVRRGQPFWLTLHFEGRNY EASVDSLTFSVVTGPAPSQEAGTKARFPLRDAVEEGDWTATVVDQQDCTL SLQLTTPANAPIGLYRLSLEASTGYQGSSFVLGHFILLFNAWCPADAVYL DSEEERQEYVLTQQGFIYQGSAKFIKNIPWNFGQFEDGILDICLILLDVN PKFLKNAGRDCSRRSSPVYVGRVVSGMVNCNDDQGVLLGRWDNNYGDGVS PMSWIGSVDILRRWKNHGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTN YNSAHDQNSNLLIEYFRNEFGEIQGDKSEMIWNFHCWVESWMTRPDLQPG YEGWQALDPTPQEKSEGTYCCGPVPVRAIKEGDLSTKYDAPFVFAEVNAD VVDWIQQDDGSVHKSINRSLIVGLKISTKSVGRDEREDITHTYKYPEGSS EEREAFTRANHLNKLAEKEETGMAMRIRVGQSMNMGSDFDVFAHITNNTA EEYVCRLLLCARTVSYNGILGPECGTKYLLNLNLEPFSGKALCSWSIC
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Molecular Weight
88 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Transglutaminase 2 (TGM2) is an important enzyme that plays diverse roles in various biological processes, including protein crosslinking, cell adhesion, and apoptosis. Research on TGM2 has gained momentum due to its implications in numerous pathologies, including neurodegenerative diseases, cancer, and cardiovascular disorders. Specifically, TGM2 has been implicated in the development of Alzheimer's disease, where it contributes to amyloid plaque formation and neuronal apoptosis. Furthermore, its overexpression in certain cancers has been associated with enhanced cell survival and tumor progression. Consequently, understanding the functional properties and regulatory mechanisms of TGM2 is crucial for developing targeted therapeutic strategies. Recombinant TGM2 protein studies have facilitated insights into its biochemical activities, substrate specificity, and potential as a biomarker for disease. The generation of recombinant TGM2 allows for controlled experimental conditions and the ability to manipulate the enzyme for functional assays, providing a clearer picture of its role in health and disease. As researchers continue to investigate TGM2's multifaceted roles, the potential for its application in diagnostics and therapeutics remains a significant area of interest.
