Analytical Data
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Gene name
TBCA
- Application
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Alternative Names
TBCA；Tubulin-specific chaperone A
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O75347
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Expression Region
2-108aa
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AA Sequence
ADPRVRQIK IKTGVVKRLV KEKVMYEKEA KQQEEKIEKM RAEDGENYDI KKQAEILQES RMMIPDCQRR LEAAYLDLQR ILENEKDLEE AEEYKEARLV LDSVKLEA
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TBCA (Tubulin Binding Co-factor A) is a significant protein that plays a crucial role in the regulation of microtubule dynamics and the assembly of the cytoskeleton, which is fundamental for various cellular functions, including mitosis, intracellular transport, and cell signaling. Research has increasingly focused on TBCA due to its involvement in cellular processes and potential implications in diseases, particularly cancer, where the dysregulation of microtubule dynamics can lead to uncontrolled cell proliferation. TBCA interacts with tubulin and stabilizes the assembly of microtubules, making it an essential co-factor in the formation and maintenance of the microtubule network. Moreover, studies have shown that TBCA may influence the activity of certain cancer therapies, highlighting its potential as a therapeutic target. Understanding the structure and function of TBCA through the study of its recombinant protein form can provide insights into its mechanistic roles in both normal and pathological states. Investigating TBCA's interactions with other cellular components and its regulatory mechanisms can lead to novel strategies for cancer treatment and a deeper understanding of cytoskeletal dynamics. Thus, the study of TBCA, particularly in its recombinant form, is vital for uncovering new avenues for therapeutic intervention in diseases where microtubule dysfunction is a key component. Through biochemical assays and structural biology techniques, researchers aim to characterize TBCA and its interactions, paving the way for future developments in targeted therapies that utilize the intricate mechanisms of microtubule regulation.
