Analytical Data
-
Gene name
ANAPC11
- Application
-
Alternative Names
ANAPC 11; ANAPC11; Anaphase promoting complex subunit 11 (yeast APC11 homolog)
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q9NYG5
-
Expression Region
1-84aa
-
AA Sequence
MKVKIKCWNG VATWLWVAND ENCGICRMAF NGCCPDCKVP GDDCPLVWGQ CSHCFHMHCI LKWLHAQQVQ QHCPMCRQEW KFKE
-
Molecular Weight
9.8 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ANAPC11, a crucial component of the anaphase-promoting complex/cyclosome (APC/C), has garnered significant interest in cell cycle regulation and its implications in cancer biology. As a ubiquitin ligase, ANAPC11 plays a vital role in promoting the degradation of specific mitotic proteins, thereby facilitating chromosomal segregation during cell division. Dysregulation of ANAPC11 activity can lead to aneuploidy and tumorigenesis, making it an important target for therapeutic interventions. Research has shown that mutations or altered expression of ANAPC11 may contribute to the development of various cancers, underscoring its potential as a biomarker for diagnosis and prognosis. Furthermore, understanding the structural and functional dynamics of ANAPC11 at the molecular level can provide insights into its mechanistic role within the APC/C and its interactions with other regulatory proteins. This knowledge could pave the way for novel cancer therapies aimed at restoring normal APC/C function or targeting its aberrant pathways in malignancies. Overall, ongoing research into ANAPC11 not only enhances our understanding of cell cycle regulation but also holds promise for advancing cancer treatment strategies.
