Analytical Data
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基因名
AKAP5
- Application
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别名
AKAP5；AKAP79；A-kinase anchor Protein 5
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P24588
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表达区间
1-427aa
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氨基酸序列
METTISEIHV ENKDEKRSAE GSPGAERQKE KASMLCFKRR KKAAKALKPK AGSEAADVAR KCPQEAGASD QPEPTRGAWA SLKRLVTRRK RSESSKQQKP LEGEMQPAIN AEDADLSKKK AKSRLKIPCI KFPRGPKRSN HSKIIEDSDC SIKVQEEAEI LDIQTQTPLN DQATKAKSTQ DLSEGISRKD GDEVCESNVS NSTTSGEKVI SVELGLDNGH SAIQTGTLIL EEIETIKEKQ DVQPQQASPL ETSETDHQQP VLSDVPPLPA IPDQQIVEEA SNSTLESAPN GKDYESTEIV AEETKPKDTE LSQESDFKEN GITEEKSKSE ESKRMEPIAI IITDTEISEF DVTKSKNVPK QFLISAENEQ VGVFANDNGF EDRTSEQYET LLIETASSLV KNAIQLSIEQ LVNEMASDDN KINNLLQ
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分子量
47 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AKAP5, or A-Kinase Anchoring Protein 5, is a crucial scaffolding protein that orchestrates localized signaling pathways by anchoring protein kinase A (PKA) and other signaling molecules to specific cellular compartments. The research on AKAP5 has gained significant attention due to its pivotal role in various physiological processes, including neuronal signaling, synaptic plasticity, and cardiac function. Dysregulation of AKAP5 has been implicated in several pathological conditions, such as heart diseases, cancer, and neurodegenerative disorders. Recent studies have highlighted the importance of AKAP5 in targeting PKA to distinct subcellular regions, facilitating the spatiotemporal control of phosphorylation events that are essential for proper cellular responses. The recombination and expression of AKAP5 protein enable researchers to dissect its functional roles and interactions in detail, providing insights into its involvement in signaling cascades. Furthermore, the development of AKAP5-targeting therapeutics holds potential for novel treatment strategies in diseases where its function is compromised. As the understanding of AKAP5's structural and functional dynamics advances, it paves the way for further exploration of its role in health and disease, making it a focal point of interest within the cell signaling and molecular biology communities.
