Analytical Data
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基因名
FOXD1
- Application
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别名
FOXD1；FKHL8；FREAC4；Forkhead box Protein D1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q16676
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表达区间
1-465aa
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氨基酸序列
MTLSTEMSDA SGLAEETDID VVGEGEDEED EEEEDDDEGG GGGPRLAVPA QRRRRRRSYA GEDELEDLEE EEDDDDILLA PPAGGSPAPP GPAPAAGAGA GGGGGGGGAG GGGSAGSGAK NPLVKPPYSY IALITMAILQ SPKKRLTLSE ICEFISGRFP YYREKFPAWQ NSIRHNLSLN DCFVKIPREP GNPGKGNYWT LDPESADMFD NGSFLRRRKR FKRQPLLPPN AAAAESLLLR GAGAAGGAGD PAAAAALFPP APPPPPHAYG YGPYGCGYGL QLPPYAPPSA LFAAAAAAAA AAAFHPHSPP PPPPPHGAAA ELARTAFGYR PHPLGAALPG PLPASAAKAG GPGASALARS PFSIESIIGG SLGPAAAAAA AAQAAAAAQA SPSPSPVAAP PAPGSSGGGC AAQAAVGPAA ALTRSLVAAA AAAASSVSSS AALGTLHQGT ALSSVENFTA RISNC
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分子量
46.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FOXD1 is a member of the forkhead box (FOX) family of transcription factors, known for its pivotal role in regulating gene expression during development and various physiological processes. Investigations into FOXD1 have garnered attention due to its involvement in nephrogenesis, suggesting a crucial role in kidney development and function. Studies have indicated that FOXD1 is essential for the proper differentiation of renal progenitor cells, influencing the formation of the nephron, the functional unit of the kidney. Moreover, dysregulation of FOXD1 expression has been implicated in several kidney-related diseases, including congenital anomalies and chronic kidney disease. The generation of recombinant FOXD1 protein serves as a valuable tool for elucidating its molecular mechanisms and biological functions. By studying the structural and functional characteristics of FOXD1, researchers aim to uncover its interaction with specific DNA sequences and other proteins, which could ultimately lead to therapeutic strategies for kidney disorders. The ability to produce and purify FOXD1 as a recombinant protein facilitates high-throughput screening assays and further investigations into its physiological and pathological roles. Continued research in this area holds promise for advancing our understanding of kidney development and pathology, potentially paving the way for innovative treatments targeting FOXD1-related pathways.
