Analytical Data
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Gene name
DOCK10
- Application
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Alternative Names
DOCK10；KIAA0694；ZIZ3；Dedicator of cytokinesis Protein 10
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96BY6
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Expression Region
全长
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AA Sequence
full
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Molecular Weight
249 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DOCK10 is a member of the DOCK (Dedicator of Cytokinesis) family of proteins, which play crucial roles in cellular processes such as cytoskeletal remodeling, cell migration, and immune responses. Research on DOCK10 has gained attention due to its involvement in various biological functions and disease mechanisms. Notably, DOCK10 has been implicated in the regulation of Rac GTPases, which are essential for actin cytoskeleton dynamics. Abnormal expression or mutations in DOCK10 have been associated with several conditions, including developmental disorders and cancers. Understanding the structure and function of DOCK10 is vital for unraveling its role in these diseases and for exploring potential therapeutic targets. Recent advances in protein engineering and structural biology techniques have facilitated the production and characterization of recombinant DOCK10 proteins, enabling researchers to investigate their functional mechanisms and interactions with other cellular components. This research is anticipated to provide insights into the fundamental processes governing cell behavior and contribute to the development of novel strategies for treating related diseases.
