Analytical Data
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Gene name
IgG2b
- Application
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Alternative Names
IgG2b；Igh-3；Immunoglobulin heavy constant gamma 2B
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Species
Mouse
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P01867
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Expression Region
97-335aa
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AA Sequence
EPSGPISTIN PCPPCKECHK CPAPNLEGGP SVFIFPPNIK DVLMISLTPK VTCVVVDVSE DDPDVQISWF VNNVEVHTAQ TQTHREDYNS TIRVVSTLPI QHQDWMSGKE FKCKVNNKDL PSPIERTISK IKGLVRAPQV YILPPPAEQL SRKDVSLTCL VVGFNPGDIS VEWTSNGHTE ENYKDTAPVL DSDGSYFIYS KLNMKTSKWE KTDSFSCNVR HEGLKNYYLK KTISRSPGL
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Molecular Weight
26 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IgG2b is a subclass of immunoglobulin G (IgG) antibodies, primarily found in certain mammals, and plays a significant role in the immune response. Its unique structure and properties have garnered attention in immunological research, particularly in understanding antibody-mediated immunity and the mechanisms underlying autoimmune diseases. Recombinant IgG2b proteins are increasingly being developed for therapeutic and diagnostic applications due to their ability to specifically bind antigens and mediate immune responses. This subclass exhibits distinct effector functions compared to other IgG isotypes, making it a valuable tool in both basic research and clinical settings. The ability to produce IgG2b in recombinant forms allows researchers to study its interactions with various antigens, optimize its binding affinity, and evaluate its potential in disease models. Furthermore, IgG2b's potential use in targeting specific pathogens or modulating immune responses in vaccine development holds promise for advancing therapeutic approaches against infectious diseases and cancers. Understanding the nuances of IgG2b's function and characteristics will not only enhance our knowledge of the immune system but also pave the way for innovative strategies in immunotherapy.
