Analytical Data
-
Gene name
CLSTN3
- Application
-
Alternative Names
CLSTN3；CS3；KIAA0726；Calsyntenin-3
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q9BQT9
-
Expression Region
20-847aa
-
AA Sequence
MASMTGGQQMGRGHHHHHHGNLYFQGGEFNKANKHKPWIEAEYQGIVMEN DNTVLLNPPLFALDKDAPLRYAGEICGFRLHGSGVPFEAVILDKATGEGL IRAKEPVDCEAQKEHTFTIQAYDCGEGPDGANTKKSHKATVHVRVNDVNE FAPVFVERLYRAAVTEGKLYDRILRVEAIDGDCSPQYSQICYYEILTPNT PFLIDNDGNIENTEKLQYSGERLYKFTVTAYDCGKKRAADDAEVEIQVKP TCKPSWQGWNKRIEYAPGAGSLALFPGIRLETCDEPLWNIQATIELQTSH VAKGCDRDNYSERALRKLCGAATGEVDLLPMPGPNANWTAGLSVHYSQDS SLIYWFNGTQAVQVPLGGPSGLGSGPQDSLSDHFTLSFWMKHGVTPNKGK KEEETIVCNTVQNEDGFSHYSLTVHGCRIAFLYWPLLESARPVKFLWKLE QVCDDEWHHYALNLEFPTVTLYTDGISFDPALIHDNGLIHPPRREPALMI GACWTEEKNKEKEKGDNSTDTTQGDPLSIHHYFHGYLAGFSVRSGRLESR EVIECLYACREGLDYRDFESLGKGMKVHVNPSQSLLTLEGDDVETFNHAL QHVAYMNTLRFATPGVRPLRLTTAVKCFSEESCVSIPEVEGYVVVLQPDA PQILLSGTAHFARPAVDFEGTNGVPLFPDLQITCSISHQVEAKKDESWQG TVTDTRMSDEIVHNLDGCEISLVGDDLDPERESLLLDTTSLQQRGLELTN TSAYLTIAGVESITVYEEILRQARYRLRHGAALYTRKFRLSCSEMNGRYS SNEFIVEVNVLHSMNRVAHPSHVLSSQQFLHRGHQPPPEMAGHSLASSHR NSMIPSA
-
Molecular Weight
96 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CLSTN3, or Cat eye syndrome critical region protein 3, is a member of the catenin family and is predominantly expressed in the brain, particularly in neurons and glial cells. Its gene is located within a genomic region associated with Cat Eye Syndrome, a congenital disorder characterized by ocular, cardiac, and renal anomalies. Recent studies have implicated CLSTN3 in crucial cellular processes such as synaptic function, cell adhesion, and signaling pathways important for neurodevelopment. The understanding of CLSTN3's role is crucial, as mutations or dysregulation of this protein may contribute to neurodevelopmental disorders and cognitive impairments. The production of recombinant CLSTN3 protein has enabled researchers to dissect its functional properties and interactions at the molecular level. By utilizing various biochemical and biophysical techniques, scientists aim to elucidate the structure-function relationship of CLSTN3, explore its role in neural networks, and assess its potential as a therapeutic target. Additionally, understanding the expression patterns and regulatory mechanisms of CLSTN3 can provide insights into its involvement in brain development and plasticity. Consequently, the study of CLSTN3 and its recombinant variants holds promise for advancing our comprehension of both normal neurodevelopment as well as the underlying mechanisms of associated disorders.
