Analytical Data
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基因名
CLSTN3
- Application
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别名
CLSTN3；CS3；KIAA0726；Calsyntenin-3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BQT9
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表达区间
20-847aa
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氨基酸序列
MASMTGGQQMGRGHHHHHHGNLYFQGGEFNKANKHKPWIEAEYQGIVMEN DNTVLLNPPLFALDKDAPLRYAGEICGFRLHGSGVPFEAVILDKATGEGL IRAKEPVDCEAQKEHTFTIQAYDCGEGPDGANTKKSHKATVHVRVNDVNE FAPVFVERLYRAAVTEGKLYDRILRVEAIDGDCSPQYSQICYYEILTPNT PFLIDNDGNIENTEKLQYSGERLYKFTVTAYDCGKKRAADDAEVEIQVKP TCKPSWQGWNKRIEYAPGAGSLALFPGIRLETCDEPLWNIQATIELQTSH VAKGCDRDNYSERALRKLCGAATGEVDLLPMPGPNANWTAGLSVHYSQDS SLIYWFNGTQAVQVPLGGPSGLGSGPQDSLSDHFTLSFWMKHGVTPNKGK KEEETIVCNTVQNEDGFSHYSLTVHGCRIAFLYWPLLESARPVKFLWKLE QVCDDEWHHYALNLEFPTVTLYTDGISFDPALIHDNGLIHPPRREPALMI GACWTEEKNKEKEKGDNSTDTTQGDPLSIHHYFHGYLAGFSVRSGRLESR EVIECLYACREGLDYRDFESLGKGMKVHVNPSQSLLTLEGDDVETFNHAL QHVAYMNTLRFATPGVRPLRLTTAVKCFSEESCVSIPEVEGYVVVLQPDA PQILLSGTAHFARPAVDFEGTNGVPLFPDLQITCSISHQVEAKKDESWQG TVTDTRMSDEIVHNLDGCEISLVGDDLDPERESLLLDTTSLQQRGLELTN TSAYLTIAGVESITVYEEILRQARYRLRHGAALYTRKFRLSCSEMNGRYS SNEFIVEVNVLHSMNRVAHPSHVLSSQQFLHRGHQPPPEMAGHSLASSHR NSMIPSA
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分子量
96 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CLSTN3, or Cat eye syndrome critical region protein 3, is a member of the catenin family and is predominantly expressed in the brain, particularly in neurons and glial cells. Its gene is located within a genomic region associated with Cat Eye Syndrome, a congenital disorder characterized by ocular, cardiac, and renal anomalies. Recent studies have implicated CLSTN3 in crucial cellular processes such as synaptic function, cell adhesion, and signaling pathways important for neurodevelopment. The understanding of CLSTN3's role is crucial, as mutations or dysregulation of this protein may contribute to neurodevelopmental disorders and cognitive impairments. The production of recombinant CLSTN3 protein has enabled researchers to dissect its functional properties and interactions at the molecular level. By utilizing various biochemical and biophysical techniques, scientists aim to elucidate the structure-function relationship of CLSTN3, explore its role in neural networks, and assess its potential as a therapeutic target. Additionally, understanding the expression patterns and regulatory mechanisms of CLSTN3 can provide insights into its involvement in brain development and plasticity. Consequently, the study of CLSTN3 and its recombinant variants holds promise for advancing our comprehension of both normal neurodevelopment as well as the underlying mechanisms of associated disorders.
