Cat: PA2000-1313

Recombinant Human CDH18 Protein,His

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Analytical Data

  • Gene name

    CDH18

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    CDH18;CDH14;Cadherin-18

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    Q13634

  • Expression Region

    54-608aa

  • AA Sequence

    MASMTGGQQMGRGHHHHHHGNLYFQGGEFGWVWNQFFVLEEHMGPDPQYV GKLHSNSDKGDGSVKYILTGEGAGTIFIIDDTTGDIHSTKSLDREQKTHY VLHAQAIDRRTNKPLEPESEFIIKVQDINDNAPKFTDGPYIVTVPEMSDM GTSVLQVTATDADDPTYGNSARVVYSILQGQPYFSVDPKTGVIRTALHNM DREAREHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQ LYVPESAQVGSAVGKIKANDADTGSNADMTYSIINGDGMGIFSISTDKET REGILSLKKPLNYEKKKSYTLNIEGANTHLDFRFSHLGPFKDATMLKIIV GDVDEPPLFSMPSYLMEVYENAKIGTVVGTVLAQDPDSTNSLVRYFINYN VEDDRFFNIDANTGTIRTTKVLDREETPWYNITVTASEIDNPDLLSHVTV GIRVLDVNDNPPELAREYDIIVCENSKPGQVIHTISATDKDDFANGPRFN FFLDERLPVNPNFTLKDNEDNTASILTRRRRFSRTVQDVYYLPIMISDGG IPSLSSSSTLTIRVCACERDGRVRTCHAEAFLSS

  • Molecular Weight

    65 kDa

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

CDH18, or Cadherin 18, is a member of the cadherin superfamily, which are integral membrane proteins known for their role in cell-cell adhesion, signaling, and tissue morphogenesis. CDH18 is primarily expressed in the central nervous system and has been implicated in various neurodevelopmental processes. Its role in modulating synaptic interactions and maintaining neuronal architecture has attracted attention in understanding neurological disorders such as autism spectrum disorders and schizophrenia. The study of CDH18 recombinant proteins facilitates insights into its functional mechanisms and interactions at the molecular level. These recombinant proteins serve as essential tools for elucidating the structural characteristics of CDH18, analyzing its binding affinities with other cadherins and synaptic proteins, and exploring its involvement in cellular pathways. Furthermore, investigating the potential dysregulation of CDH18 expression in neurological diseases could unveil new therapeutic targets or biomarkers. Thus, research on CDH18 recombinants is crucial for deciphering complex neuronal network behaviors and offers opportunities for developing novel strategies in treating neurodevelopmental disorders.

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