Analytical Data
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基因名
KATNB1
- Application
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别名
KATNB1；Katanin p80 WD40 repeat-containing subunit B1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BVA0
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表达区间
1-655aa
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氨基酸序列
MATPVVTKTA WKLQEIVAHA SNVSSLVLGK ASGRLLATGG DDCRVNLWSI NKPNCIMSLT GHTSPVESVR LNTPEELIVA GSQSGSIRVW DLEAAKILRT LMGHKANICS LDFHPYGEFV ASGSQDTNIK LWDIRRKGCV FRYRGHSQAV RCLRFSPDGK WLASAADDHT VKLWDLTAGK MMSEFPGHTG PVNVVEFHPN EYLLASGSSD RTIRFWDLEK FQVVSCIEGE PGPVRSVLFN PDGCCLYSGC QDSLRVYGWE PERCFDVVLV NWGKVADLAI CNDQLIGVAF SQSNVSSYVV DLTRVTRTGT VARDPVQDHR PLAQPLPNPS APLRRIYERP STTCSKPQRV KQNSESERRS PSSEDDRDER ESRAEIQNAE DYNEIFQPKN SISRTPPRRS EPFPAPPEDD AATAKEAAKP SPAMDVQFPV PNLEVLPRPP VVASTPAPKA EPAIIPATRN EPIGLKASDF LPAVKIPQQA ELVDEDAMSQ IRKGHDTMCV VLTSRHKNLD TVRAVWTMGD IKTSVDSAVA INDLSVVVDL LNIVNQKASL WKLDLCTTVL PQIEKLLQSK YESYVQTGCT SLKLILQRFL PLITDMLAAP PSVGVDISRE ERLHKCRLCY KQLKSISGLV KSKSGLSGRH GSTFRELHLL MASLD
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分子量
72.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KATNB1, or Katanin Protein Catalytic Subunit B1, is a critical protein involved in microtubule severing, a fundamental process in cellular dynamics and cytoskeletal organization. Recent research has highlighted its essential role in various cellular functions, including mitosis, cell migration, and the maintenance of neuronal structure. Abnormalities in KATNB1 expression or function have been linked to several neurodegenerative diseases and developmental disorders, making it a significant target for both basic and applied biomedical research. The recombinant production of KATNB1 has become increasingly important for studying its biochemical properties and functional mechanisms in laboratory settings. By generating KATNB1 as a recombinant protein, researchers can conduct more controlled experiments to dissect its interactions with microtubules and other cellular components, as well as explore its potential as a therapeutic target. Furthermore, understanding the structure-function relationship of KATNB1 through recombinant studies can provide insights into the underlying molecular mechanisms of diseases associated with microtubule dysregulation, thus paving the way for novel therapeutic strategies. Overall, the investigation of KATNB1 recombinant protein not only enriches our knowledge of cytoskeletal dynamics but also holds promise for clinical applications in addressing disorders linked to its dysfunction.
