Analytical Data
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Gene name
SOSTDC1
- Application
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Alternative Names
SOSTDC1;USAG1;Sclerostin domain-containing Protein 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6X4U4
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Expression Region
24-206aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSFKNDATE ILYSHVVKPV PAHPSSNSTL NQARNGGRHF SNTGLDRNTR VQVGCRELRS TKYISDGQCT SISPLKELVC AGECLPLPVL PNWIGGGYGT KYWSRRSSQE WRCVNDKTRT QRIQLQCQDG STRTYKITVV TACKCKRYTR QHNESSHNFE SMSPAKPVQH HRERKRASKS SKHSMS
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Molecular Weight
23 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SOSTDC1, a member of the SOST family of proteins, plays a crucial role in the regulation of bone and cartilage development. It is primarily expressed in tissues such as the growth plate and osteoblasts, contributing to the modulation of Wnt signaling pathways, which are vital for bone homeostasis and metabolism. Research has demonstrated that SOSTDC1 acts as an antagonist to Wnt signaling, inhibiting the differentiation of osteoblasts and promoting chondrogenesis. Dysregulation of SOSTDC1 has been associated with various skeletal disorders, including osteoporosis and congenital malformations. Given its significant role in skeletal biology, scientists are keen on characterizing and producing recombinant SOSTDC1 protein to study its functional mechanisms in detail. The production of SOSTDC1 as a recombinant protein allows for in vitro experimentation, enabling researchers to explore its interactions with other signaling molecules and unravel its influence on osteogenic and chondrogenic pathways. Ultimately, a deeper understanding of SOSTDC1 could pave the way for novel therapeutic strategies for bone-related diseases, making it a focal point of current biomedical research.
