Analytical Data
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基因名
SNAI2
- Application
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别名
SNAI2;SLUG;SLUGH;Zinc finger Protein SNAI2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O43623
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表达区间
1-268aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSMPRSFLVKKHFNASKKPNYSELDTHTV IISPYLYESYSMPVIPQPEILSSGAYSPITVWTTAAPFHAQLPNGLSPLS GYSSSLGRVSPPPPSDTSSKDHSGSESPISDEEERLQSKLSDPHAIEAEK FQCNLCNKTYSTFSGLAKHKQLHCDAQSRKSFSCKYCDKEYVSLGALKMH IRTHTLPCVCKICGKAFSRPWLLQGHIRTHTGEKPFSCPHCNRAFADRSN LRAHLQTHSDVKKYQCKNCSKTFSRMSLLHKHEESGCCVAH
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分子量
32 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SNAI2, a member of the Snail family of transcription factors, plays a critical role in embryonic development and various cellular processes, including epithelial-mesenchymal transition (EMT), which is pivotal in both normal development and cancer metastasis. The reprogramming of epithelial cells into mesenchymal cells, facilitated by SNAI2, enables increased mobility and invasiveness, contributing to tumor progression and the spread of cancer cells. Numerous studies have indicated that SNAI2 is overexpressed in several cancers, linking its activity to poor prognosis and therapeutic resistance. Given these implications, researchers are increasingly focused on characterizing SNAI2's structure and function at the molecular level, investigating its regulatory mechanisms and downstream targets. Understanding SNAI2's role could reveal new therapeutic targets for inhibiting cancer metastasis and improving treatment strategies. Consequently, the production and characterization of recombinant SNAI2 protein have become essential for elucidating its biochemical properties and interactions within cellular pathways, which could lead to novel insights into its role in pathology and potential applications in targeted therapies.
