Analytical Data
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基因名
SH2D1A
- Application
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别名
SH2D1A;DSHP;SAP;SH2 domain-containing Protein 1A
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O60880-1
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表达区间
1-128aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MDAVAVYHGK ISRETGEKLL LATGLDGSYL LRDSESVPGV YCLCVLYHGY IYTYRVSQTE TGSWSAETAP GVHKRYFRKI KNLISAFQKP DQGIVIPLQY PVEKKSSARS TQGTTGIRED PDVCLKAP
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分子量
16 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SH2D1A, also known as Src Homology 2 Domain-containing Protein 1A, plays a critical role in T-cell signaling and immune response regulation. This protein functions primarily as an adaptor in various cellular processes, particularly in the context of immune system modulation, where it interacts with signaling molecules to influence T-cell activation and proliferation. Dysregulation of SH2D1A has been implicated in several immunological disorders, including X-linked lymphoproliferative disease, which highlights its importance in maintaining lymphocyte homeostasis. Recent studies have sought to elucidate the structural and functional characteristics of SH2D1A through recombinant protein expression, enabling researchers to investigate its interactions and mechanisms at a molecular level. Understanding the properties of SH2D1A can provide insights into its role in immune signaling pathways and contribute to the development of potential therapeutic strategies for conditions associated with immune dysregulation. The advent of advanced expression systems and purification techniques allows for the production of high-quality recombinant SH2D1A, facilitating detailed biochemical and biophysical analyses critical for advancing our knowledge in immunology and regenerative medicine.
