Analytical Data
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Gene name
NTAN1
- Application
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Alternative Names
NTAN1; Protein N-terminal asparagine amidohydrolase; EC 3.5.1.121; Protein NH2-terminal asparagine amidohydrolase; PNAA; Protein NH2-terminal asparagine deamidase; PNAD; Protein N-terminal Asn amidase; Protein N-terminal asparagine amidase; Protein NTN-amidase
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96AB6
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Expression Region
2-310 aa
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AA Sequence
PLLVEGRRV RLPQSAGDLV RAHPPLEERA RLLRGQSVQQ VGPQGLLYVQ QRELAVTSPK DGSISILGSD DATTCHIVVL RHTGNGATCL THCDGTDTKA EVPLIMNSIK SFSDHAQCGR LEVHLVGGFS DDRQLSQKLT HQLLSEFDRQ EDDIHLVTLC VTELNDREEN ENHFPVIYGI AVNIKTAEIY RASFQDRGPE EQLRAARTLA GGPMISIYDA ETEQLRIGPY SWTPFPHVDF WLHQDDKQIL ENLSTSPLAE PPHFVEHIRS TLMFLKKHPS PAHTLFSGNK ALLYKKNEDG LWEKISSPGS
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Molecular Weight
34.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The NTAN1 (N-terminal asparagine amidase 1) protein has emerged as a significant focus in the field of biochemical research due to its role in the degradation of N-terminal asparagine residues. These residues are often modified post-translationally, which can impact protein stability, localization, and function. Understanding the mechanisms by which NTAN1 functions is crucial, as it is involved in various cellular processes, including protein quality control and responses to cellular stress. Research has shown that NTAN1 is implicated in several diseases, including neurodegenerative disorders, where the accumulation of misfolded proteins leads to cellular dysfunction. Furthermore, NTAN1's enzymatic activity presents a potential target for therapeutic interventions, making it an area of interest for drug development. Scientists are exploring the structural biology of NTAN1 to better understand its enzymatic properties and regulatory mechanisms. Advances in recombinant protein technology have enabled researchers to produce NTAN1 in sufficient quantities for detailed study, paving the way for potential applications in biotechnology and medicine. Thus, NTAN1 represents a promising subject for ongoing research that could yield insights into both fundamental biological processes and the development of novel therapeutic strategies.
