Analytical Data
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Gene name
AAAS
- Application
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Alternative Names
AAAS; ADRACALA; GL003Aladin; Adracalin
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NRG9
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Expression Region
2-546aa
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AA Sequence
CSLGLFPPP PPRGQVTLYE HNNELVTGSS YESPPPDFRG QWINLPVLQL TKDPLKTPGR LDHGTRTAFI HHREQVWKRC INIWRDVGLF GVLNEIANSE EEVFEWVKTA SGWALALCRW ASSLHGSLFP HLSLRSEDLI AEFAQVTNWS SCCLRVFAWH PHTNKFAVAL LDDSVRVYNA SSTIVPSLKH RLQRNVASLA WKPLSASVLA VACQSCILIW TLDPTSLSTR PSSGCAQVLS HPGHTPVTSL AWAPSGGRLL SASPVDAAIR VWDVSTETCV PLPWFRGGGV TNLLWSPDGS KILATTPSAV FRVWEAQMWT CERWPTLSGR CQTGCWSPDG SRLLFTVLGE PLIYSLSFPE RCGEGKGCVG GAKSATIVAD LSETTIQTPD GEERLGGEAH SMVWDPSGER LAVLMKGKPR VQDGKPVILL FRTRNSPVFE LLPCGIIQGE PGAQPQLITF HPSFNKGALL SVGWSTGRIA HIPLYFVNAQ FPRFSPVLGR AQEPPAGGGG SIHDLPLFTE TSPTSAPWDP LPGPPPVLPH SPHSHL
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Molecular Weight
59.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The research on AAAS (Allgroove Syndrome) recombinant proteins has gained significant attention due to its implications in understanding the underlying mechanisms of this rare genetic disorder. AAAS is caused by mutations in the AAAS gene, which encodes the protein ALADIN, a critical component of the nucleocytoplasmic transport system. ALADIN plays an essential role in cellular processes, including nuclear transport, mitochondrial function, and the maintenance of genomic stability. Patients with Allgroove Syndrome exhibit a combination of adrenal insufficiency, alacrima (absence of tear production), and achalasia, making it crucial to explore the functional deficits caused by the mutations in the AAAS gene. By utilizing recombinant DNA technology, researchers can produce purified AAAS proteins for in-depth studies of their structure, function, and interactions within the cell. This research is vital for developing potential therapeutic strategies, as it provides insights into how the altered protein may disrupt normal cellular activities, leading to the symptoms of Allgroove Syndrome. Understanding the molecular basis of AAAS through recombinant protein studies could pave the way for identifying biomarkers for early diagnosis and innovative treatments for affected individuals. Overall, the exploration of AAAS recombinant proteins not only contributes to the field of genetic disorders but also enhances our knowledge of fundamental cellular processes involving nucleocytoplasmic transport.
