Analytical Data
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基因名
TPC
- Application
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别名
TPC；KIAA1169；TPC1；Two pore channel Protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q16204
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表达区间
2-474aa
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氨基酸序列
ADSASESDT DGAGGNSSSS AAMQSSCSST SGGGGGGGGG GGGGKSGGIV ISPFRLEELT NRLASLQQEN KVLKIELETY KLKCKALQEE NRDLRKASVT IQARAEQEEE FISNTLFKKI QALQKEKETL AVNYEKEEEF LTNELSRKLM QLQHEKAELE QHLEQEQEFQ VNKLMKKIKK LENDTISKQL TLEQLRREKI DLENTLEQEQ EALVNRLWKR MDKLEAEKRI LQEKLDQPVS APPSPRDISM EIDSPENMMR HIRFLKNEVE RLKKQLRAAQ LQHSEKMAQY LEEERHMREE NLRLQRKLQR EMERREALCR QLSESESSLE MDDERYFNEM SAQGLRPRTV SSPIPYTPSP SSSRPISPGL SYASHTVGFT PPTSLTRAGM SYYNSPGLHV QHMGTSHGIT RPSPRRSNSP DKFKRPTPPP SPNTQTPVQP PPPPPPPPMQ PTVPSAATSQ PTPSQHSAHP SSQP
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分子量
53.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of TPC recombinant proteins has garnered significant attention in recent years due to their potential applications in various fields, including biotechnology, medicine, and pharmacology. TPC, or Two-Pore Channels, are a family of ion channels that play crucial roles in regulating cellular calcium homeostasis and various physiological processes. Understanding their structure and function is essential for elucidating their roles in health and disease, particularly in the context of neurodegenerative disorders, cardiac diseases, and cancer. The recombinant expression of TPC proteins allows researchers to investigate their biochemical properties, interactions, and regulatory mechanisms in detail. Advances in genetic engineering and protein purification techniques have enabled the production of these proteins in heterologous systems, facilitating detailed studies on their functionality and potential as therapeutic targets. By harnessing the power of recombinant technology, scientists aim to develop novel therapeutic strategies that can modulate TPC activity, offering new avenues for treatment of diseases linked to calcium dysregulation. As the field continues to evolve, the integration of multidisciplinary approaches, including structural biology, electrophysiology, and pharmacology, will further enhance our understanding of TPC proteins and their significance in human health.
