Analytical Data
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Gene name
NT5DC2
- Application
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Alternative Names
NT5DC2; 5'-nucleotidase domain-containing protein 2; EC 3.1.3.-
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H857
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Expression Region
1-520 aa
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AA Sequence
MRVESGSAQE RGILLESLST LLEKTTASHE GRAPGNRELT DLLPPEVCSL LNPAAIYANN EISLRDVEVY GFDYDYTLAQ YADALHPEIF STARDILIEH YKYPEGIRKY DYNPSFAIRG LHYDIQKSLL MKIDAFHYVQ LGTAYRGLQP VPDEEVIELY GGTQHIPLYQ MSGFYGKGPS IKQFMDIFSL PEMALLSCVV DYFLGHSLEF DQAHLYKDVT DAIRDVHVKG LMYQWIEQDM EKYILRGDET FAVLSRLVAH GKQLFLITNS PFSFVDKGMR HMVGPDWRQL FDVVIVQADK PSFFTDRRKP FRKLDEKGSL QWDRITRLEK GKIYRQGNLF DFLRLTEWRG PRVLYFGDHL YSDLADLMLR HGWRTGAIIP ELEREIRIIN TEQYMHSLTW QQALTGLLER MQTYQDAESR QVLAAWMKER QELRCITKAL FNAQFGSIFR TFHNPTYFSR RLVRFSDLYM ASLSCLLNYR VDFTFYPRRT PLQHEAPLWM DQLCTGCMKT PFLGDMAHIR
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Molecular Weight
60.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NT5DC2, or 5'-nucleotidase domain-containing protein 2, is a member of the nucleotidase family that plays a crucial role in nucleotide metabolism and cellular signaling. Its involvement in various physiological and pathological processes has drawn significant attention in recent years. Research indicates that NT5DC2 may be implicated in the regulation of immune responses, as well as the development of certain cancers, making it a potential biomarker and therapeutic target. The enzyme is known to hydrolyze nucleotides, thereby influencing adenosine levels in the microenvironment, which can modulate inflammation and tumorigenesis. Given its significance in disease mechanisms, there is an increasing demand for NT5DC2 recombinant protein for in-depth studies. This protein can be used in assays to explore its enzymatic activity, interactions with other cellular components, and its role in signaling pathways. The production of NT5DC2 as a recombinant protein allows researchers to overcome the challenges associated with its purification from natural sources, facilitating investigations into its biological functions and potential applications in drug development. Understanding NT5DC2's structure and function will not only enhance our knowledge of nucleotide metabolism but also pave the way for novel therapeutic strategies targeting related disorders. As the field progresses, further research on NT5DC2 will likely contribute to the development of innovative approaches in cancer therapy and immunomodulation.
