Analytical Data
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Gene name
NSE1
- Application
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Alternative Names
LRATD1; FAM84A; NSE1; Protein LRATD1; LRAT domain-containing 1; Neurologic sensory protein 1; NSE1; Protein FAM84A
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96KN4
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Expression Region
1-292 aa
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AA Sequence
MGNQLDRITH LNYSELPTGD PSGIEKDELR VGVAYFFSDD EEDLDERGQP DKFGVKAPPG CTPCPESPSR HHHHLLHQLV LNETQFSAFR GQECIFSKVS GGPQGADLSV YAVTALPALC EPGDLLELLW LQPAPEPPAP APHWAVYVGG GQIIHLHQGE IRQDSLYEAG AANVGRVVNS WYRYRPLVAE LVVQNACGHL GLKSEEICWT NSESFAAWCR FGKREFKAGG EVPAGTQPPQ QQYYLKVHLG ENKVHTARFH SLEDLIREKR RIDASGRLRV LQELADLVDD KE
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Molecular Weight
32.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NSE1 (NEDD8-STAR EXORHIXIDASE 1) is a crucial protein implicated in various cellular processes, including cell cycle regulation, DNA repair, and protein degradation. It serves as a component of the NEDD8 conjugation machinery, which modifies target proteins through the attachment of the ubiquitin-like protein NEDD8. This modification plays a significant role in controlling protein stability and activity, impacting processes such as apoptosis and oncogenesis. Recent studies have highlighted the involvement of NSE1 in the pathogenesis of several diseases, including cancer, where altered expression levels can contribute to tumor progression and resistance to therapies. Additionally, NSE1 has been linked to neurodegenerative diseases, underscoring its importance in maintaining cellular homeostasis. Given its multifaceted role in critical biological pathways, NSE1 has emerged as a potential therapeutic target. The development of NSE1 recombinant proteins and their derivatives can facilitate the study of its functional mechanisms and interactions with other cellular components. Understanding NSE1's structure-function relationship may pave the way for novel therapeutic strategies aimed at modulating its activity, offering promising avenues for intervention in diseases where NSE1 is implicated. As researchers continue to explore the reprogramming of NSE1 through recombinant protein technology, insights gained could elucidate broader implications for therapeutic applications in regenerative medicine and targeted cancer therapies.
