Analytical Data
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基因名
NSD1
- Application
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别名
NIZP1; NSD1 (nuclear receptor binding SET-domain containing 1)-interacting zinc finger protein 1; NSD1-interacting zinc finger protein 1; Zinc finger protein 496; Zinc finger protein with KRAB and SCAN domains 17; ZKSCAN17; ZN496_HUMAN; ZNF496
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96IT1
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表达区间
1-587 aa
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氨基酸序列
MPTALCPRVL APKESEEPRK MRSPPGENPS PQGELPSPES SRRLFRRFRY QEAAGPREAL QRLWDLCGGW LRPERHTKEQ ILELLVLEQF LAILPREIQS WVRAQEPESG EQAVAAVEAL EREPGRPWQW LKHCEDPVVI DDGDSPLDQE QEQLPVEPHS DLAKNQDAQP ITLAQCLGLP SRPPSQLSGD PVLQDAFLLQ EENVRDTQQV TTLQLPPSRV SPFKDMILCF SEEDWSLLDP AQTGFYGEFI IGEDYGVSMP PNDLAAQPDL SQGEENEPRV PELQDLQGKE VPQVSYLDSP SLQPFQVEER RKREELQVPE FQACPQTVVP QNTYPAGGNP RSLENSLDEE VTIEIVLSSS GDEDSQHGPY CTEELGSPTE KQRSLPASHR SSTEAGGEVQ TSKKSYVCPN CGKIFRWRVN FIRHLRSRRE QEKPHECSVC GELFSDSEDL DGHLESHEAQ KPYRCGACGK SFRLNSHLLS HRRIHLQPDR LQPVEKREQA ASEDADKGPK EPLENGKAKL SFQCCECGKA FQRHDHLARH RSHFHLKDKA RPFQCRYCVK SFTQNYDLLR HERLHMKRRS KQALNSY
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分子量
66.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NSD1 (Nuclear Receptor-Binding SET Domain Protein 1) is a member of the SET domain protein family, playing a crucial role in chromatin remodeling and gene expression regulation. Mutations and dysregulation of NSD1 have been linked to various developmental disorders, including Sotos syndrome and certain cancers, underscoring its significance in cellular processes. Given its involvement in histone methylation and interaction with transcription factors, NSD1 is a key player in epigenetic regulation. The study of recombinant NSD1 protein allows researchers to explore its biochemical properties, molecular interactions, and functional mechanisms in greater detail. By producing NSD1 in a controlled laboratory setting, scientists can investigate its enzymatic activity, binding affinities, and effects on target genes, which are critical for understanding its role in normal physiology and pathology. Furthermore, recombinant NSD1 protein serves as a valuable tool for drug discovery and therapeutic interventions aimed at modulating its activity. Overall, the research on NSD1 and its recombinant forms is vital for elucidating its contributions to genomic stability, development, and disease.
