Analytical Data
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Gene name
ITPR3
- Application
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Alternative Names
ITPR3；Inositol 1.4.5-trisphosphate receptor type 3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14573
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Expression Region
全长
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AA Sequence
full
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Molecular Weight
304 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ITPR3, or Inositol 1,4,5-trisphosphate receptor type 3, is a critical protein involved in intracellular calcium signaling, playing a pivotal role in various physiological processes, including muscle contraction, neurotransmitter release, and cellular apoptosis. Its dysfunction has been implicated in several diseases, such as neurodegenerative disorders, cancer, and cardiovascular diseases, making it a significant target for therapeutic intervention. Research into the recombinant expression and purification of ITPR3 has gained momentum in recent years, driven by the need to understand its structure and function more effectively. By generating recombinant ITPR3 proteins, scientists can investigate the receptor's binding mechanisms, activation pathways, and regulatory interactions with other cellular components. Additionally, elucidating the structural details of ITPR3 can provide insights into its role in pathophysiology and aid in the design of specific inhibitors or modulators. The ability to produce high-quality, functional ITPR3 protein in heterologous systems has been essential for advancing our understanding of its biochemistry and its implications in human health and disease. Overall, the recombinant study of ITPR3 not only holds promise for basic research but also paves the way for potential clinical applications in targeting diseases associated with calcium signaling dysregulation.
