Analytical Data
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基因名
NRK
- Application
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别名
C9orf95; Nicotinamide riboside kinase 1; Nicotinic acid riboside kinase 1; Nik-related protein kinase; NRK 1; NRK; NRK_HUMAN; Ribosylnicotinamide kinase 1; Ribosylnicotinic acid kinase 1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q7Z2Y5
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表达区间
1483-1582 aa
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氨基酸序列
VEANEQLFKKILEMWKDIPSSIAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHHSRVYFMTLGKLEELQSNYDV
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分子量
36.63 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NRK (Nuclear Receptor Kinase) proteins play a critical role in the regulation of various cellular processes, including transcription, signal transduction, and cell differentiation. Understanding the functions and mechanisms of NRK proteins is crucial given their implications in various diseases, including cancer and metabolic disorders. Research has increasingly focused on the role of NRK proteins in modulating the activity of nuclear receptors, which are essential for the action of many hormones and other signaling molecules. This regulatory capability positions NRK proteins as potential targets for therapeutic intervention. Moreover, recent advances in structural biology have enabled scientists to elucidate the intricate interactions between NRK proteins and their substrates. These insights are paving the way for the development of innovative strategies to manipulate NRK activity for therapeutic benefit. Given the complexity of the signaling pathways involved and the diverse roles of NRK proteins in the cell, ongoing research aims to dissect their precise functions and regulatory mechanisms. Such studies not only enhance our understanding of basic cellular biology but also hold promise for developing new treatments for diseases where NRK proteins are implicated.
