Analytical Data
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基因名
AP3s2
- Application
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别名
AP3s2；AP-3 complex subunit sigma-2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P59780
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表达区间
1-193aa
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氨基酸序列
MIQAILVFNN HGKPRLVRFY QRFPEEIQQQ IVRETFHLVL KRDDNICNFL EGGSLIGGSD YKLIYRHYAT LYFVFCVDSS ESELGILDLI QVFVETLDKC FENVCELDLI FHMDKVHYIL QEVVMGGMVL ETNMNEIVAQ IEAQNRLEKS EGGLSAAPAR AVSAVKNINL PEIPRNINIG DLNIKVPNLS QFV
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分子量
22 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AP3s2, or Adaptor Protein Complex 3 Sigma-2 subunit, is a crucial component of the AP-3 complex, which plays a significant role in intracellular trafficking, particularly in the transport of proteins to lysosomes and related organelles. Research into AP3s2 has gained attention due to its involvement in various cellular processes, including endocytosis, membrane trafficking, and the sorting of proteins containing specific signals. Deficiencies or mutations in AP3s2 have been linked to several neurodegenerative diseases and developmental disorders, highlighting its biological significance. Understanding the structure and function of AP3s2 at the molecular level can provide insights into its role in these pathological conditions, potentially identifying new therapeutic targets. The recombinant expression of AP3s2 allows for detailed biochemical and biophysical characterization, aiding in the elucidation of its interaction networks and functional mechanisms within the cell. Recent advancements in purification techniques and structural biology, such as cryo-electron microscopy, have further accelerated research efforts aimed at comprehensively mapping the AP3 complex and its diverse roles in cellular homeostasis. By exploring AP3s2 through recombinant protein studies, researchers hope to unravel its complexities and contribute to the broader understanding of vesicular trafficking and its implications in human health and disease.
